Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-22T16:53:57.906Z Has data issue: false hasContentIssue false
  • English
  • Français

Epstein-Barr virus antibody in cases and contacts of infectious mononucleosis; a family study

Published online by Cambridge University Press:  15 May 2009

F. J. Nye  and
H. P. Lambert
F. J. Nye
Affiliation:
Communicable Diseases Unit, St George's Hospital, London, S. W. 17
H. P. Lambert
Affiliation:
Communicable Diseases Unit, St George's Hospital, London, S. W. 17
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Serological investigations were carried out on 147 patients with Paul—Bunnell positive infectious mononucleosis (IM) from the general population. All possessed antibody to the Epstein—Barr virus (EBV) and 63% showed serological evidence of recent infection. Contacts of 132 patients, 306 in all, were followed serologically; within 6 months of the index cases' illness twenty one contacts developed evidence of EBV infection or re-infection and of these five developed overt IM. The secondary attack rate of EBV infection among susceptible contacts was at least 19%; the corresponding figure for clinically apparent IM was 6%. EBY antibody prevalence among patients' siblings was significantly lower than among age-matched controls, suggesting that cases of IM come from families with a lower than normal previous experience of the virus. Of thirteen patients with persistently Paul—Bunnell negative ‘glandular fever’ four had serological evidence of recent EBV infection and two had probable cytomegalovirus mononucleosis. Recent EBV infection may have been associated with the illnesses of five of the remaining patients.

Type
Research Article
Information
Journal of Hygiene , Volume 71 , Issue 1 , March 1973 , pp. 151 - 161
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Brumfitt, W. & O'Grady, F. (1957). Slide screening test for Glandular Fever. Journal of Clinical Pathology 10, 243.CrossRefGoogle ScholarPubMed
Davidsohn, I. & Henry, J. (1968). In Clinical Diagnosis by Laboratory Methods. 14th Ed. (Philadelphia: Saunders).Google Scholar
Davidsohn, I. & Lee, C. L. (1969). In Infectious Mononucleosis. Ed. Carter, R. L. and Penman, H. G.. Oxford and Edinburgh: Blackwell Scientific Publications.Google Scholar
Epstein, M. A. (1970). Aspects of the EB virus. Advances in Cancer Research 3, 383.CrossRefGoogle Scholar
Evans, A. S., Niederman, J. C. & McCollum, B. W. (1968). Sero-epidemiologic studies of Infectious Mononucleosis with EB virus. New England Journal of Medicine 279, 1121.CrossRefGoogle Scholar
Evans, A. S., Rothfield, N. F. & Niederman, J. C. (1971). Raised antibody titres to EB virus in systemic lupus erythematosus. Lancet i, 167.CrossRefGoogle Scholar
Golden, H. D., Chang, R. S., Lou, J. J. & Cooper, T. Y. (1971). A filterable agent in throat washings of patients with infectious mononucleosis. Journal of Infectious Diseases 124, 422.CrossRefGoogle ScholarPubMed
Henle, G. & Henle, W. (1966). Immunofluorescence in cells derived from Burkitt's lymphoma. Journal of Bacteriology 91, 1248.CrossRefGoogle ScholarPubMed
Henle, G. & Henle, W. (1970). Observations on childhood infections with Epstein-Barr virus. Journal of Infectious Diseases 121, 303.CrossRefGoogle ScholarPubMed
Henle, G., Henle, W. & Diehl, V. (1968). Relation of Burkitt's tumour — associated Herpestype virus to infectious mononucleosis. Proceedings of the National Academy of Sciences of the U.S.A. 59, 94.CrossRefGoogle Scholar
Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G. W., Kirya, B. G., Klein, G., Morrow, B. H., Munube, G.M. R., Pike, P., Tukei, P. M. & Ziegler, J. L. (1969). Antibodies to Epstein—Barr virus in Burkitt's lymphoma and control groups. Journal of the National Cancer Institute 43, 1147.Google ScholarPubMed
Hirsraut, Y., Glade, P., Moses, H., Manaker, R. & Chessin, L. (1969). Association of Herpes-like virus infection with infectious mononucleosis. American Journal of Medicine 47, 520.CrossRefGoogle Scholar
Hirshaut, Y., Glade, P., Vieira, L. O. B. D., Ainbender, E., Dvorak, B. & Siltzbach, L. E. (1970). Sarcoidosis, another disease associated with serologic evidence for herpes-like infection. New England Journal of Medicine 283, 502.CrossRefGoogle ScholarPubMed
Joncas, J. & Mitnyan, C. (1970). Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts. Canadian Medical Association Journal 102, 1260.Google ScholarPubMed
Lee, C. L., Davidsohn, I. & Slaby, R. (1968). Horse agglutinins in infectious mononucleosis. American Journal of Clinical Pathology 49, 3.CrossRefGoogle ScholarPubMed
Niederman, J. C., McCollum, R. W., Henle, G. & Henle, W. (1968). Infectious Mononucleosis. Clinical manifestations in relation to EB virus antibodies. Journal of the American Medical Association 203, 139.Google ScholarPubMed
Niederman, J. C., Evans, A. S., Subrahmanyan, L. & McCollum, R. W. (1970). Prevalence, incidence, and persistence of EB virus antibody in young adults. American Journal of Medicine 282, 361.Google ScholarPubMed
Papageorgiou, P. S., Sorokin, C., Koutzouzakoglou, K. & Glade, P. R. (1971). Herpeslike Epstein—Barr virus in leprosy. Nature, London 231, 47.CrossRefGoogle ScholarPubMed
Pereira, M. S., Blake, J. M. & Macrae, A. D. (1969). EB virus antibody at different ages. British Medical Journal iv, 526.CrossRefGoogle Scholar
Pereira, M. S., Field, A. M., Blake, J. M., Rodgers, F. G., Bailey, L. A. & Davies, J. R. (1972). Evidence for oral excretion of EB virus in infectious mononucleosis. Lancet i, 710.CrossRefGoogle Scholar
Porter, D. D., Wimberley, I. & Benyesh-Melnick, M. (1969). Prevalence of antibodies to EB virus and other herpes viruses. Journal of the American Medical Association 208, 1675.CrossRefGoogle Scholar
Sabin, A. B. & Feldman, H. A. (1948). Dyes and microchemical indicators of a new immunity phenomenon affecting a protozoan parasite (Toxoplasma). Science, New York 108, 660.CrossRefGoogle Scholar
Stern, H. & Elek, S. D. (1965). The incidence of infection with cytomegalovirus in a normal population. A serological study in Greater London. Journal of Hygiene 63, 79.CrossRefGoogle Scholar
Stewart, G. L., Parkman, P. D., Hopps, H. E., Douglas, R. D., Hamilton, J. P. & Meyer, H. M. (1967). Rubella-virus haemagglutination-inhibition test. New England Journal of Medicine 276, 554.CrossRefGoogle Scholar
University Health Physicians and P.H.L.S. Joint Investigation (1971). Infectious mononucleosis and its relationship to EB virus antibody. British Medical Journal iv, 643.Google Scholar
Wahren, B., Lantorp, K., Sterner, G. & Espmark, A. (1970). EBV antibodies in family contacts of patients with Infectious Mononucleosis. Proceedings of the Society for Experimental Biology and Medicine 133, 934.CrossRefGoogle ScholarPubMed