Enteroviruses in Spain: virological and epidemiological studies over 10 years (1988–97)

G. TRALLERO; I. CASAS; A. TENORIO; J. E. ECHEVARRIA; A. CASTELLANOS; A. LOZANO; P. P. BREÑA

doi:10.1017/S0950268899003726

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A total of 15662 clinical samples were analysed for enterovirus (EV) isolation in cell cultures during a 10-year period (1988–97). Furthermore, 210 isolates of EV obtained in primary laboratories within Spain from patients with meningitis were characterized. The total number of EV typed was 758, including 727 non-polio EV and 31 Sabin-like (SL) polioviruses. Twenty-eight EV serotypes were represented. Echoviruses comprised 90% (653/727) of fully typed non-polio EV. The four most prevalent serotypes were echovirus 30, echovirus 9, echovirus 6 and echovirus 4. Echovirus 30 was the main serotype associated with meningitis. Echovirus 9 was the aetiological agent in 20 outbreaks of meningitis while the occurrence of echovirus 6 was localized in 1 year (1997). Coxsackieviruses A and B occurred in 3 and 7% of the non-polio EV respectively. Coxsackievirus B5 presented the relative greater abundance. This paper examines the epidemiology of EV in Spain to serotype level over a 10-year period with special attention to non-polio EV associated with meningitis.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Casas, I. Palacios, G.F. Trallero, G. Cisterna, D. Freire, M.C. and Tenorio, A. 2001. Molecular characterization of human enteroviruses in clinical samples: Comparison between VP2, VP1, and RNA polymerase regions using RT nested PCR assays and direct sequencing of products. Journal of Medical Virology, Vol. 65, Issue. 1, p. 138.

de la Loma, Asia Trallero, Gloria de Ory, Fernando Tenorio, Antonio Sanz, Margarita and Echevarría, J. Manuel 2002. Meningitis linfocitaria en España: posible situación epidémica en el año 2000. Medicina Clínica, Vol. 118, Issue. 18, p. 694.

Palacios, G. Casas, I. Cisterna, D. Trallero, G. Tenorio, A. and Freire, C. 2002. Molecular Epidemiology of Echovirus 30: Temporal Circulation and Prevalence of Single Lineages. Journal of Virology, Vol. 76, Issue. 10, p. 4940.

Avellón, Ana Casas, Inmaculada Trallero, Gloria Pérez, Carmen Tenorio, Antonio and Palacios, Gustavo 2003. Molecular Analysis of Echovirus 13 Isolates and Aseptic Meningitis, Spain. Emerging Infectious Diseases, Vol. 9, Issue. 8, p. 934.

Pérez, Carmen José Pena, María Molina, Lourdes Trallero, Gloria García, Amós Álamo, Fayna and Lafarga, Bernardo 2003. Brote epidémico de meningitis por virus Echo serotipo 13 en la isla de Gran Canaria. Enfermedades Infecciosas y Microbiología Clínica, Vol. 21, Issue. 7, p. 340.

Coiras, M.T. Aguilar, J.C. García, M.L. Casas, I. and Pérez‐Breña, P. 2004. Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested‐PCR assays. Journal of Medical Virology, Vol. 72, Issue. 3, p. 484.

Rezig, Dorra Yahia, Ahlem Ben Abdallah, Hager Ben Bahri, Olfa and Triki, Hinda 2004. Molecular characterization of coxsackievirus B5 isolates. Journal of Medical Virology, Vol. 72, Issue. 2, p. 268.

Bahri, O Rezig, D Nejma-Oueslati, B Ben Yahia, A Ben Sassi, J Ben Hogga, N Sadraoui, A and Triki, H 2005. Enteroviruses in Tunisia: virological surveillance over 12 years (1992–2003). Journal of Medical Microbiology , Vol. 54, Issue. 1, p. 63.

Lamarão, Letícia Martins Gomes, Maria de Lourdes Contente Ferreira, Lauze Lee Alves Fonseca, Cleide Mara Araújo, Lia C.B. Santana, Marquete B. and Tavares-Neto, José 2005. Pesquisa de enterovírus em casos de síndrome de meningite asséptica de Belém, PA. Revista da Sociedade Brasileira de Medicina Tropical, Vol. 38, Issue. 5, p. 391.

Zhao, Ya Nan Jiang, Qing Wu Jiang, Ren Jie Chen, Liang and Perlin, David S. 2005. Echovirus 30, Jiangsu Province, China. Emerging Infectious Diseases, Vol. 11, Issue. 4, p. 562.

Palacios, G and Oberste, MS 2005. Enteroviruses as agents of emerging infectious diseases. Journal of Neurovirology, Vol. 11, Issue. 5, p. 424.

Clancy, Leighton E. Craig, Maria E. White, Peter A. and Rawlinson, William D. 2005. Human enterovirus isolates from an outbreak typed using heteroduplex mobility analysis. Journal of Medical Virology, Vol. 76, Issue. 2, p. 215.

Dumaidi, Kamal Frantzidou, Filanthi Papa, Anna Diza, Eudoxia and Antoniadis, Antonis 2006. Enterovirus meningitis in Greece from 2003–2005: diagnosis, CSF laboratory findings, and clinical manifestations. Journal of Clinical Laboratory Analysis, Vol. 20, Issue. 5, p. 177.

Cherry, James D. 2006. Infectious Diseases of the Fetus and Newborn Infant. p. 783.

Trallero, Gloria Avellón, Ana Otero, Almudena de Miguel, Teresa Alonso, Milagros and Pérez-Breña, Pilar 2006. Red de Laboratorios del Plan de Erradicación de la Poliomielitis (1998-2003): 6 años de vigilancia de parálisis flácida aguda en España. Enfermedades Infecciosas y Microbiología Clínica, Vol. 24, Issue. 3, p. 167.

dos Santos, Gina P.L. Skraba, Irene Oliveira, Denise Lima, Ana A.F. de Melo, Maria Mabel M. Kmetzsch, Claudete I. da Costa, Eliane V. and da Silva, Edson E. 2006. Enterovirus meningitis in Brazil, 1998–2003. Journal of Medical Virology, Vol. 78, Issue. 1, p. 98.

Mistchenko, Alicia Susana Viegas, Mariana Latta, Maria Paula Della and Barrero, Paola Roxana 2006. Molecular and epidemiologic analysis of enterovirus B neurological infection in Argentine children. Journal of Clinical Virology, Vol. 37, Issue. 4, p. 293.

Witsø, Elisabet Palacios, Gustavo Cinek, Ondrej Stene, Lars C. Grinde, Bjørn Janowitz, Diana Lipkin, W. Ian and Rønningen, Kjersti S. 2006. High Prevalence of Human Enterovirus A Infections in Natural Circulation of Human Enteroviruses. Journal of Clinical Microbiology, Vol. 44, Issue. 11, p. 4095.

Tseng, Fan‐Chen Huang, Han‐Chin Chi, Chia‐Yu Lin, Tsuey‐Li Liu, Ching‐Chuan Jian, Jhih‐Wei Hsu, Li‐Ching Wu, Ho‐Sheng Yang, Jyh‐Yuan Chang, Ya‐Wen Wang, Hsuan‐Chen Hsu, Yun‐Wei Su, Ih‐Jen and Wang, Jen‐Ren 2007. Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: Analysis of sentinel physician surveillance data. Journal of Medical Virology, Vol. 79, Issue. 12, p. 1850.

Belguith, K. Bouslama, L. Sdiri, K. Nsaibia, S. and Ouni, M. 2007. Génotypes d'échovirus 6 circulant dans la région de Monastir. Pathologie Biologie, Vol. 55, Issue. 7, p. 316.

Download full list

Article contents

Enteroviruses in Spain: virological and epidemiological studies over 10 years (1988–97)

Abstract

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests