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Enhancement of the infectivity of Fusobacterium necrophorum by other bacteria

Published online by Cambridge University Press:  15 May 2009

G. R. Smith ,
D. Till ,
L. M. Wallace  and
D. E. Noakes
G. R. Smith
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
D. Till
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
L. M. Wallace
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY
D. E. Noakes
Affiliation:
Department of Surgery and Obstetrics, Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA
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Necrobacillosis is caused by Fusobacterium necrophorum (FN), but other organisms are often present in the lesions. Their possible role was studied in experiments made with a virulent FN strain which, by itself, produced fatal necrobacillosis in mice provided that large doses ( > 106 organisms, subcutaneously) were given. Mice were inoculated subcutaneously with FN suspended in sub-lethal doses (0·1 ml) of undiluted or diluted broth cultures of other bacteria. Undiluted culture of a strain of Escherichia coli reduced the infective dose of FX to < 10 organisms: in the necrobacillosis lesions that developed, fusobacteria greatly outnumbered E. coli. A heat-killed preparation or sterile filtrate of E. coli culture had little if any effect on FN. Citrobacter freundii and comparativelv small numbers of Corynebacterium (Actinomyces) pyogenes produced effects similar to that of E. coli. An α-haemolvtic streptococcus. Pseudomonas aeruginosa. Bacteroides fragilis and Fusobacterium nudeatum also enhanced the infectivity of FN. though less strikingly than E. coli. FN increased the persistence in vivo of the α-haemolytic streptococcus and B. fragilis, and enabled the latter to multiply profusely.

Type
Special Article
Information
Epidemiology & Infection , Volume 102 , Issue 3 , June 1989 , pp. 447 - 458
Copyright
Copyright © Cambridge University Press 1989

References

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