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The effects of oxytetracycline on the intestinal Escherichia coli flora of newly weaned pigs

Published online by Cambridge University Press:  19 October 2009

M. Hinton ,
D. J. Hampson ,
Elisabeth Hampson  and
A. H. Linton
M. Hinton
Affiliation:
Department of Veterinary Medicine, University of Bristol, Langford House, Langford, Avon, BS18 7DU
D. J. Hampson
Affiliation:
Department of Veterinary Medicine, University of Bristol, Langford House, Langford, Avon, BS18 7DU
Elisabeth Hampson
Affiliation:
Department of Veterinary Medicine, University of Bristol, Langford House, Langford, Avon, BS18 7DU
A. H. Linton
Affiliation:
Department of Microbiology, Medical School, University of Bristol, University Walk, Bristol, BS8 1TD
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Summary

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Four recently weaned pigs were dosed orally with oxytetracycline. This caused a rapid increase in the incidence of tetracycline resistance (TcR) among Escherichia coli isolates from the faecal flora. The isolates were differentiated further on the basis of O-serogroup, biotype and resistance pattern. There was no evidence that the administration of the antibiotic selected for a few TcR clones, but rather a relatively large number of TcR strains were identified during the dosing period. Using selective isolation media a proportion of these strains were demonstrated in the minority faecal Esch. coli flora before dosing, while the remainder were recognized for the first time after dosing commenced.

The incidence of TcR among Esch. coli isolates also increased after weaning in other pigs which were not dosed with oxytetracycline or any other antibacterial agent. In a proportion of these animals this increase was associated with the dominance of a TcR enteropathogenic serotype (0149:K 91, K 88a, c) in the faecal Esch. coli flora which was probably ingested in small numbers before weaning. The source of other TcR strains was probably the environment in which each pig was placed after weaning.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 1 , August 1985 , pp. 77 - 85
Copyright
Copyright © Cambridge University Press 1985

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