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The effects of life-long subsistence on diets providing suboptimal amounts of the “Vitamin B complex”

Published online by Cambridge University Press:  15 May 2009

J. C. Drummond ,
Audrey Z. Baker ,
Margaret D. Wright ,
Phyllis M. Marrian  and
Eleanor M. Singer
J. C. Drummond
Affiliation:
From the Biochemical Department, University College, London and Research Laboratories, Vitamins Ltd., Hammersmith, London
Audrey Z. Baker
Affiliation:
From the Biochemical Department, University College, London and Research Laboratories, Vitamins Ltd., Hammersmith, London
Margaret D. Wright
Affiliation:
From the Biochemical Department, University College, London and Research Laboratories, Vitamins Ltd., Hammersmith, London
Phyllis M. Marrian
Affiliation:
From the Biochemical Department, University College, London and Research Laboratories, Vitamins Ltd., Hammersmith, London
Eleanor M. Singer
Affiliation:
From the Biochemical Department, University College, London and Research Laboratories, Vitamins Ltd., Hammersmith, London
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1. A comparative study has been made of the life history of two groups of rats, one of which (483 animals) was maintained on an adequate diet whilst the other (556 animals) was given a ration providing a suboptimal intake of “vitamin B”. The chief defect of the second diet was probably in respect to vitamin B1.

2. The duration of life was shortened and reproduction was adversely affected by the deficiency.

3. The examination of the post-mortem records provides clear proof of a significantly greater incidence of gastro-intestinal lesions, particularly ulcerations, in the animals on the deficient diet than in the control group.

4. The deficiency of B1 did not influence the incidence or the severity of the chronic lung infection (bronchiectasis) common in laboratory rats.

5. The incidence of all other disorders was about the same in the two groups.

6. No evidence of increased susceptibility to tumours, malignant or innocent, was shown by the animals on the deficient diet. Cancerous developments arising at the site of chronic inflammatory processes (e.g. worm cysts in the liver, caecal ulcers of long standing, etc.) were not appreciably more numerous in one group than in the other.

Type
Research Article
Information
Journal of Hygiene , Volume 38 , Issue 3 , May 1938 , pp. 356 - 373
Copyright
Copyright © Cambridge University Press 1938

References

REFERENCES

Alvarez, W. C., Pilcher, F., Foley, M. A., Mayer, A. & Osterburg, A. E. (1936). Amer. J. Digest. Dis. Nutrit. 2, 102.CrossRefGoogle Scholar
Aron, P. & Van Der Rijst, M. (1936). Arch. néerl. Physiol. 21, 274.Google Scholar
Baker, A. Z. & Drummond, J. C. (1937). J. Soc. Chem. Ind., Lond., 56, 191 T.Google Scholar
Baker, A. Z. & Wright, M. D. (1935). Biochem. J. 29, 1802.T.CrossRefGoogle Scholar
Baker, A. Z. & Wright, M. D. (1936). Proc. Roy. Soc. Med. 29, 49.Google Scholar
Brich, T. W., György, P. & Harris, L. J. (1935). Biochem. J. 29, 2830.CrossRefGoogle Scholar
Bourne, M. C. & Pyke, M. A. (1935). Biochem. J. 29, 1865.CrossRefGoogle Scholar
Bullock, F. D. & Curtis, M. R. (1930). J. Cancer Res. 14, 1.Google Scholar
Chatterjee, D. D. (1935). Ind. J. Med. Res. 23, 191.Google Scholar
Clemmenson, S. (1933). Acta path. microbiol. scand. 10, 315.CrossRefGoogle Scholar
Cowgill, G. R. (1934). The Vitamin B Requirements of Man. Yale Univ. Press.Google Scholar
Cowgill, G. R., Deuel, J. H., Plummer, N. & Messer, F. C. (1926). Amer. J. Physiol. 77, 389.CrossRefGoogle Scholar
Cowgill, G. R. & Gilman, A. (1935). Arch. Int. Med. 53, 58.CrossRefGoogle Scholar
Dalldorf, G. & Kellogg, M. (1932). J. Exp. Med., 56, 391.CrossRefGoogle Scholar
Day, P. L., Langston, W. C. & O'Brien, C. S. (1931). Amer. J. Ophthal. 14, 1005.CrossRefGoogle Scholar
Day, P. L. & Langston, W. C. (1934). J. Nutrit. 7, 97.CrossRefGoogle Scholar
Donaldson, H. H. (1924). The Rat, 2nd ed.Philadelphia.Google Scholar
Dodds, E. C., Noble, R. L. & Smith, E. R. (1934). Lancet, 2, 918.CrossRefGoogle Scholar
Dodds, E. C., Hills, G. M., Noble, R. L. & Williams, P. C. (1935). Lancet, 1, 1099.CrossRefGoogle Scholar
Drummond, J. C. (1934). Biochemical Studies of Nutritional Problems. Stanford Univ. Press.Google Scholar
Edgar, C. E. & Macrae, T. F. (1937). Biochem. J. 31, 886, 893.CrossRefGoogle Scholar
Elsom, K. O. (1934). J. Clin. Invest. 13, 716.Google Scholar
Evans, H. M. & Lepkovsky, S. (1929). J. Biol. Chem. 83, 269.CrossRefGoogle Scholar
Findlay, G. M. (1928). J. Path. Bact. 31, 353.CrossRefGoogle Scholar
Fridericia, L. S. (1934). Dansk. Med. Selsk. 1, 16.Google Scholar
Fujimaki, K. (1926). J. Cancer Res. 10, 469.Google Scholar
Keith Simpson, C. (1936). Guy's Hosp. Rep. 86, 120.Google Scholar
Komarov, S. A. (1934). Guy's Hosp. Rep. 32, 398.Google Scholar
Lepkovsky, S., Jukes, T. H. & Krause, M. E. (1936). J. Biol. Chem. 115, 557.CrossRefGoogle Scholar
Lloyd, E. M. H. (1936). J. Proc. Agric. Econ. Soc. 4, 89.Google Scholar
Marks, H. (1932). Med. J. Rec. 2 March.Google Scholar
McCarrison, R. (1931). Ind. J. Med. Res. 19, 61.Google Scholar
Moll, T., Domagk, G. & Laquer, F. (1933). Klin. Wschr. 12, 465.CrossRefGoogle Scholar
Orr, Sir J. B. (1936). Food, Health and Income. London.Google Scholar
Passey, R. D., Leese, S. & Knox, J. C. (1926). J. Path. Bact. 42, 425.CrossRefGoogle Scholar
Plimmer, R. H. & Plimmer, V. G. (1933). Food, Health and Vitamins. 6th ed.CrossRefGoogle Scholar
Richards, M. B. & Simpson, B. W. (1934). Biochem. J. 28, 274.CrossRefGoogle Scholar
Schiödt, E. (1935). Ada med. scand. 84, 456.CrossRefGoogle Scholar
Slonaker, J. R. (1912). J. Anim. Behav. 2, 20.CrossRefGoogle Scholar
Sparks, M. I. & Collins, E. N. (1935). Amer. J. Digest. Dis. Nutrit. 2, 618.CrossRefGoogle Scholar
Sure, B. (1927). J. Biol. Chem. 74, 55.CrossRefGoogle Scholar
Sure, B. (1928). J. Biol. Chem. 76, 659.CrossRefGoogle Scholar
Sure, B., Kik, M. C. & Buchanan, K. S. (1935). Proc. Soc. Exp. Biol. Med. 33, 78.CrossRefGoogle Scholar
Webster, D. R. & Armouk, J. C. (1932). Proc. Soc. Exp. Biol. Med. 30, 1297.CrossRefGoogle Scholar