Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T23:36:41.714Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of chloramphenicol on Chlamydia trachomatis infection in neonatal conjunctivitis and in McCoy cell cultures

Published online by Cambridge University Press:  25 March 2010

D. Hobson ,
D. Stefanidis ,
E. Rees  and
I. A. Tait
D. Hobson
Affiliation:
Department of Medical Microbiology, The University of Liverpool, Liverpool L69 3BX
D. Stefanidis
Affiliation:
Department of Medical Microbiology, The University of Liverpool, Liverpool L69 3BX
E. Rees
Affiliation:
Department of Venereology, Royal Liverpool Hospital, Liverpool L7 8XW
I. A. Tait
Affiliation:
Department of Venereology, Royal Liverpool Hospital, Liverpool L7 8XW
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

It was found that 26 of 127 infants with chlamydial conjunctivitis had previously received chloramphenicol eye drops. This treatment had delayed the onset and reduced the degree of oedema, congestion and discharge compared with infected infants with no ‘first-line’ chemotherapy, but eye swabs remained positive in 22 (85 %) of the chloramphenicol treated infants.

The problems of designing laboratory tests which might accurately forecast the clinical value, or lack of value of antibiotics in chlamydial infections were investigated. The minimum inhibitory concentration (MIC) of chloramphenicol, against Chlamydia trachomatis in McCoy cell cultures varied widely according to the antibiotic preparation used, the timing and duration of its exhibition in relation to the single step growth cycle of C. trachomatis, and, in particular, the method of examination of infected tissue cultures for residual chlamydial growth after incubation with chloramphenicol.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 3 , December 1982 , pp. 457 - 466
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bushell, A. C. & Hobson, D. (1978). Effeet of Cortisol on the growth of Chlamydia trachomatis in McCoy cells. Infection and Immunity 21, 946–953.CrossRefGoogle Scholar
Davies, J. A., Rees, E., Hobson, D. & Karayiannis, P. (1978). Isolation of Chlamydia trachomatis from Bartholin's ducts. British Journal of Venereal Diseases 54, 409–413.Google ScholarPubMed
Garrod, L. P., Lambert, H. P. & O'Grady, F. (1981). Antibiotic &: Chemotherapy 5th ed., p. 491. Edinburgh: Churchill Livingstone.Google Scholar
Hobson, D., Karayiannis, P.Byng, H. K., Rees, K., & Tait, I. A. (1980). Quantitative aspects of chlamydial infection of the cervix. British Journal of Venereal Diseases 56, 56 62.Google ScholarPubMed
Hobson, D., Lee, N.. Bushell, A. C. & Withana, N. (1982). The activity of β lactam antihiotics against Chlamydia trachomatisin McCoy cellcultures. In Chlamydial Infection (ed. Márdh, P. A., Holmes, K. K., Oriel, J. D., Piot, P. & Schachter, J.), pp. 249 252. Amsterdam: Elsevier.Google Scholar
Johnson, F. W. A. & Hobson, D. (1977). The effect of penicillin on genital strains of Chamydia trachomatis in tissue culture. Journal of Antimicrobial Chemotherapy 3, 49–56.CrossRefGoogle Scholar
Karayiannis, P. & Hobson, D. (1981 a). The role of calf serum in the growth of Chlamydia trachomatis in McCoy cell cultures. Journal of General Microbiology 122, 47–54.Google ScholarPubMed
Karayiannis, P. & Hobson, D. (1981 b). Amino-acid requirements of a Chlamydia trachomatis genital strain in McCoy cell cultures. Journal of Clinical Microbiology 13, 427–432.CrossRefGoogle ScholarPubMed
Kro, C. C., Wang, S.-P. & Grayston, J. T. (1977). Antimicrobial activity of several antibiotics against Chlamydia trachomatis organisms in cell culture. Antimicrobial Agents d Chemotherapy 12, 80–89.Google Scholar
Manire, G. P. (1977). Biological characteristics of chlamydiae. In Nongonococal l'rethritis and Related Infections (ed. Hobson, D. & Holmes, K. K.), pp. 167–175. Washington. D.C.: American Society of Microbiology.Google Scholar
Oriel, J. D. & Ridgeway, G. L. (1982). Genital infections by Chlamydia trachomatis. Pp. 14–19. London: Edward Arnold.Google ScholarPubMed
Rees, K., Tait, I. A., Hobson, D., Byng, R. K. & Johnson, F. W. A. (1977 a). Neonatal conjunctivitis caused by Neisseria gonorrhoeae and Chlamydia trachomatis. British Journal of Venereal Diseases 53, 173–179.Google ScholarPubMed
Rees, E., Tait, I. A., Hobson, D. & Johnson, F. W. A. (1977 b). Perinatal Chlamydial infection. In Nongonococcal l'rethritis and Related Infections (ed. Hobson, D. & Holmes, K. K.). pp. 140–147. Washington.D.C.: American Society of Microbiology.Google Scholar
Rees, K., Tait, I. A., Hobson, D., Karayiannis, P. & Lee, N. (1981). Persistence of chlamydial infection after treatment for neonatal conjunctivitis. Archives of Diseases in Childhood 56, 193–198CrossRefGoogle ScholarPubMed
Treharne, J. D.Day, J.Yeo, C. K., Jones, B. R. & Squires, S. (1977). Susceptibility of chlamydiae to chemotherapeutic agents. In Nongonococcal l'rethritis and Related Infections (ed. Hobson, D. & Holmes, K. K.), pp. 214–222. Washington. D. C.: American Society of Microbiology.Google Scholar