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The Effect of Particle Size on the Toxicity of α-Naphthyl Thiourea (Antu) to Albino Rats

Published online by Cambridge University Press:  15 May 2009

E. W. Bentley
Affiliation:
Ministry of Agriculture, Fisheries and Food, Infestation Control Division, Tolworth, Surbiton, Surrey
Yvonne Larthe
Affiliation:
Ministry of Agriculture, Fisheries and Food, Infestation Control Division, Tolworth, Surbiton, Surrey
A. Taylor
Affiliation:
Ministry of Agriculture, Fisheries and Food, Infestation Control Division, Tolworth, Surbiton, Surrey
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Summary

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1. Particles of antu of 5 μ diameter were significantly less toxic to domestic rats than particles of 50–55 μ.

2. In each of three bio-assays they were less toxic than particles of antu of 100–110 μ.

3. It is concluded that the specification for antu for use in poison baits against R. norvegicus should not require it to be in the form of fine particles.

This work was initiated at the suggestion of Dr E. E. Turtle of this Division, and his advice during its progress is gratefully acknowledged. Thanks are also due to Mr L. E. Hammond for much help in the preparation of the test doses, and to Dr H. Egan and Mr E. I. Johnson of the Government Chemist's staff who carried out a number of the many micro-weighings involved.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1955

References

Byerrum, R. U. (1946). Influence of dietary iodine on susceptibility of rats to alpha-naphthylthiourea poisoning. Proc. Soc. exp. Biol., N.Y., 62, 328.CrossRefGoogle ScholarPubMed
Chitty, D. & Southern, H. N. (1954). Control of Rats and Mice. Oxford: Clarendon Press.Google Scholar
Dieke, S. H. & Richter, C. P. (1946). Age and species variation in the acute toxicity of alpha-naphthylthiourea. Proc. Soc. exp. Biol., N.Y., 62, 22.CrossRefGoogle Scholar
Elmore, J. W. (1948). Report on rodenticides. J. Ass. off. agric. Chem., Wash., 31, 366.Google Scholar
Finney, D. J. (1947). Probit Analysis. Cambridge University Press.Google Scholar
Gaines, T. B. & Hayes, W. J. (1952). Bait shyness to antu in wild Norway rats. Publ. Hlth Rep., Wash., 67, 306.CrossRefGoogle ScholarPubMed
Latven, A. R., Sloane, A. B. & Munch, J. C. (1948). Antu, the lethal dose. Soap, N.Y., 24, 127, 129, 131.Google ScholarPubMed
McClosky, W. T. & Smith, M. I. (1945). Studies on the pharmacologic action and the pathology of alpha-naphthylthiourea (Antu). I. Pharmacology. Publ. Hlth Rep., Wash., 60, 1101.CrossRefGoogle Scholar
Meyer, B. J. & Karel, L. (1948 a). The effects of iodides, l-thiosorbitol, and twenty-five other compounds on alphanaphthylthiourea (ANTU) toxicity in rats. J. Pharmacol. 92, 15.Google Scholar
Meyer, B. J. & Karel, L. (1948 b). Effect of environmental temperature on alphanaphthylthiourea (ANTU) toxicity to rats. J. Pharmacol. 93, 420.Google Scholar
Münchberg, P. (1951). Zur Chemie, Technologie und Toxicologie der Nagergifte in Vergangenheit und Gegenwart. Schädlingsbekämpfung, 43, 123.Google Scholar
Rall, D. P. & North, W. C. (1952). Toxicity of antu for the rat and its lack of dependence upon body weight. Fed. Proc. 2, 383.Google Scholar
Richter, C. P. (1945). The development and use of alpha-naphthylthiourea (Antu) as a rat poison. J. Amer. med. Ass. 129, 927.CrossRefGoogle ScholarPubMed
Rogers, P. V. (1946). Relation between sex hormones and changes in susceptibility of domestic Norway rats to alpha-naphthyl thiourea. Proc. Soc. exp. Biol., N.Y., 63, 38.CrossRefGoogle ScholarPubMed
Schwartze, E. W. (1922). The significance of the marked variations in the toxicity of undissolved arsenious oxide. J. Pharmacol. 19, 258.Google Scholar
Stokes, C. G. (1846). The theories of the internal friction of fluids in motion and of the equilibrium and motions of elastic solids. Phil. Mag. 29, 60.Google Scholar