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The ecology and epidemiology of the pig-bel syndrome in man in New Guinea

Published online by Cambridge University Press:  15 May 2009

T. G. C. Murrell ,
J. R. Egerton ,
Anita Rampling ,
Janet Samels  and
P. D. Walker
T. G. C. Murrell
Affiliation:
Department of Public Health, Kundiawa, New Guinea
J. R. Egerton
Affiliation:
Department of Agriculture, Stock and Fisheries, Konedobu, Papua
Anita Rampling
Affiliation:
Department of Agriculture, Stock and Fisheries, Konedobu, Papua
Janet Samels
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
P. D. Walker
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
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1. Features in the epidemiology of a spontaneous enteric gangrene in the Highlands of New Guinea are described.

2. The disease has been called pig-bel because of its firm association with the pig-feasting practices of the people, which occur in 3–7 year cycles.

3. Cl. welchii type C is believed to play an important role in the pathogenesis of the condition. Strains isolated were strongly toxigenic and uniform in their toxin production.

4. A food poisoning aetiology was not proved but circumstantial and immunological evidence suggest that pork may be a vector of the disease.

5. The source of Cl. welchii type C was not established.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 3 , September 1966 , pp. 375 - 396
Copyright
Copyright © Cambridge University Press 1966

References

REFERENCES

Bailey, K. V. & Whiteman, J. (1963). Dietary studies in the Chimbu (New Guinea Highlands). Trop. geogr. Med. 15, 377.Google ScholarPubMed
Bennetts, H. W. (1932). Infectious enterotoxaemia (the so-called braxy-like disease) of sheep in Western Australia. Bull. Coun. scient. ind. Res., Melb. 57.Google Scholar
Bishop, R. E. & Allcock, E. A. (1960). Bacterial flora of the small intestine in acute intestinal obstruction. Br. med. J. i, 766.CrossRefGoogle Scholar
Bosworth, T. J. (1940–1943). On a new type of toxin produced by Cl. Welchii. J. comp. Path. 53, 245.CrossRefGoogle Scholar
Brookfield, H. C. & Brown, P. (1959). Chimbu land and society. Oceania 30, 1.Google Scholar
Bullen, J. J. & Scarisbrick, R. (1957). Enterotoxaemia of sheep: experimental reproduction of the disease. J. Path. Bact. 73, 495.CrossRefGoogle Scholar
Campbell, C. H. & Arthur, A. (1964). A study of 2000 admissions to the medical ward of the Port Moresby General Hospital. Med. J. Aust. i, 989.CrossRefGoogle Scholar
Dalling, T. (1928). Lamb dysentery. Vet. Rec. 8, 841.Google Scholar
Department of Public Health, Territory of Papua and New Guinea (1962–1963). Hospital Disease Statistics.Google Scholar
Dische, F. E. & Elek, S. D. (1957). Experimental food poisoning by Cl. welchii. Lancet ii, 71.CrossRefGoogle Scholar
Egerton, J. R. & Murrell, T. G. C. (1965). Intestinal emphysema in pigs in the Western Highlands of New Guinea. J. comp. Path. 74, 35.CrossRefGoogle Scholar
Egerton, J. R. & Walker, P. D. (1964). The isolation of Clostridium perfringens type C from necrotic enteritis of man in Papua–New Guinea. J. Path. Bact. 88, 275.CrossRefGoogle ScholarPubMed
Egerton, J. R. (1966). Bacteriological investigation of necrotic enteritis. Papua New Guin. med. J. (in the Press).Google Scholar
Ernst, O. (1948). Epidemiologische Beitrag zur Enteritis necroticans. Dte Gesundh Wes. 3, 262.Google Scholar
Field, H. I. & Gibson, E. A. (1955). Studies on piglet mortality; Clostridium welchii infection. Vet. Rec. 67, 31.Google Scholar
Field, H. I. & Goodwin, R. F. W. (1959). The experimental reproduction of enterotoxaemia in piglets. J. Hyg., Camb. 57, 81.CrossRefGoogle ScholarPubMed
Glenny, A. T., Barr, M., Llewellyn-Jones, M., Dalling, T. & Ross, H. E. (1933). Multiple toxins produced by some organisms of the Cl. welchii group. J. Path. Bact. 37, 53.CrossRefGoogle Scholar
Glenny, A. T., Llewellyn-Jones, M. & Mason, J. H. (1931). The intracutaneous method of testing the toxins and antitoxins of the gas gangrene organisms. J. Path. Bact. 34, 201.CrossRefGoogle Scholar
Griessman, H. (1950). Über den Darmbrand Arch. klin. Chir. 254, 1.Google Scholar
Griner, L. A. & Bracken, F. K. (1953). Cl. perfringens (type C) in acute haemorrhagic enteritis of calves. J. Am. vet. med. Ass. 122, 99.Google Scholar
Hain, E. (1949). Origin of Cl. welchii type F infection. Br. med. J. i, 271.Google Scholar
Hansen, K., Jeckeln, E., Jochims, J., Lezius, A., Meyer-Burgdorff, H. & Schütz, F. (1949). Darmbrand—Enteritis Necroticans. Stuttgart: Georg Thiem, Verlag.Google Scholar
Hobbs, B. C., Smith, M. E., Oakley, C. L., Warrack, G. H. & Cruickshank, J. C. (1953). Clostridium welchii food poisoning. J. Hyg., Camb. 51, 75.CrossRefGoogle ScholarPubMed
Hormann, H. (1948). Zur Ätiologie der nekrotisierenden Enteritis. Klin. Wschr. 26, 319.Google Scholar
Jeckeln, E. (1957). Fortschritte und Probleme im der Dünndarm pathologie. Verh. dt. Ges. inn. Med. 63, 404.Google Scholar
Jochims, J. (1947). Klinische Beobachtungen über den akuten Darmbrand junger Kinder. Dtsch. med. Wschr. 72, 166.CrossRefGoogle Scholar
Kloos, K. & Brummund, W. (1951). Epidemiologische Studien über die Enteritis gravis in Nordostholstein (ausser Lübeck). Z. Hyg. InfektKrankh. 132, 64.CrossRefGoogle ScholarPubMed
McEwen, A. D. (1930). B. paludis: A new species of pathogenic anaerobic bacterium. J. comp. Path. 43, 1.CrossRefGoogle Scholar
Marcuse, K. & König, J. (1950). Bakteriologishe Befunde bei Jejunitis nekroticans. Zentbl. Bakt. ParasitKde. Abt I, Orig. 156, 107.Google Scholar
Meggitt, M. J. (1958). The Enga, of the New Guinea Highlands. Some preliminary observations. Oceania 28, 253.CrossRefGoogle Scholar
Murrell, T. G. C. (1966) Pig-bel—Enteritis necroticans. M.D. Thesis, University of Adelaide.CrossRefGoogle Scholar
Murrell, T. G. C. & Roth, L. (1963). Necrotizing jejunitis: A newly discovered disease in the Highlands of New Guinea. Med. J. Aust. i, 61.CrossRefGoogle Scholar
Murrell, T. G. C., Roth, L., Egerton, J. R., Samels, J. & Walker, P. D. (1966). Pig-bel—enteritis necroticans. A study in diagnosis and management. Lancet i, 217.CrossRefGoogle Scholar
Nilles, J. (1950). The Kuman of the Chimbu Region, Central Highlands, New Guinea. Oceania 21, 25.CrossRefGoogle Scholar
Nissen, G. (1950). Cited by Kloos L. & Brummund W. (1951). Z. Hyg. InfektKrankh. 132, 64.Google Scholar
Oakley, C. L. (1949). The toxins of Cl. welchii type F. Br. med. J. i, 269.Google Scholar
Oomen, H. A. P. C. & Malcolm, S. H. (1958). Nutrition and the Papuan child. Tech. Pap. S. Pacif. Commn. 118.Google Scholar
Ordway, N. K. (1960). Diarrhoeal disease and its control. Bull. Wld Hlth Org. 23, 73.Google ScholarPubMed
Pietzonka, H. & Rassfeld-Sternberg, L. (1950). Weitere bakteriologisch gesicherte fälle von Enteritis necroticans in Hamburg und Ditmarschen (März 1948 bis März 1949). Klin. Wschr. 28, 425.CrossRefGoogle ScholarPubMed
Roantree, W. B. (1949). Spontaneous paralytic ileus. Br. J. Surg. 36, 352.CrossRefGoogle ScholarPubMed
Schütz, F. (1948). Zur Atiologie der nekrotisierenden Enteritis. Medsche Klin. 43, 341.Google Scholar
Scragg, R. F. R. (1954). Depopulation in New Ireland. A study of demography and fertility. M.D. Thesis, University of Adelaide.Google Scholar
Siegmund, H. (1948). Zur Pathologie und Pathogenese der als Darmbrand bezeichneten Enteritis necroticans. Klin. Wschr. 26, 33.CrossRefGoogle Scholar
Sterne, M. & Warrack, G. H. (1964). The types of Clostridium perfringens. J. Path. Bact. 88, 279.CrossRefGoogle ScholarPubMed
Venkatachalam, P. S. (1962). A study of the diet, nutrition and health of the people of the Chimbu area. Department of Public Health, Territory of Papua and New Guinea, Monograph, no. 4.Google Scholar
Yasnogorodsky, A. Y. (1936). Vyestn. Khir. 44, 67. Abstr. Zent. Org. Chir. (1937) 84, 498.Google Scholar
Zeissler, J. & Rassfeld-Sternberg, L. (1949). Enteritis necroticans due to Clostridium welchii type F. Br. med. J. i, 267.CrossRefGoogle Scholar