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Ecological effects of antibiotic production by dermatophyte fungi

Published online by Cambridge University Press:  15 May 2009

Nagwan Youssef
Affiliation:
Life Sciences, Polytechnic of Central London, New Cavendish Street, London W1M 8J5
C. H. E. Wyborn
Affiliation:
Life Sciences, Polytechnic of Central London, New Cavendish Street, London W1M 8J5
G. Holt
Affiliation:
Life Sciences, Polytechnic of Central London, New Cavendish Street, London W1M 8J5
W. C. Noble
Affiliation:
institute of Dermatology, St John's Hospital for Diseases of the Skin, London E9 6BX
Yvonne M. Clayton
Affiliation:
institute of Dermatology, St John's Hospital for Diseases of the Skin, London E9 6BX
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Summary

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Antibiotic production by dermatophyte fungi has been demonstrated in vivo in the lesions of patients with dermatomycoses. Patients infected with antibiotic-producing strains more frequently carried cocci resistant to penicillin and other antibiotics than did patients infected with non-producer strains. The total bacterial load was less in lesions caused by producer fungi. In vitro studies demonstrated the selection of penicillin-resistant S. aureus from mixed populations of resistant and sensitive cells.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Arvidson, S., Holme, T. & Lindholm, B. (1972). The formation of extracellular proteolytic enzymes by Staphylococcus aureus. Acta pathologica et microbiologica scandinavica B 80, 835–44.Google ScholarPubMed
Bibel, D. J. & LeBrun, J. R. (1975). Effect of experimental dermatophyte infection on cutaneous flora. Journal of Investigative Dermatology 64, 119–23.CrossRefGoogle ScholarPubMed
Cowan, S. T. & Steel, K. J. (1974). Manual for the Identification of Medical Bacteria. Cambridge University Press.Google Scholar
King, R. D., Dillavou, C. L., Greenberg, J. H., Jeppson, J. C. & Jaegar, J. S. (1976). Identification of carbon dioxide as a dermatophyte inhibitory factor produced by Candida albicans. Canadian Journal of Microbiology 22, 1720–27.CrossRefGoogle ScholarPubMed
Knight, A. G. (1973). Human models for the in vivo and in vitro assessment of topical antifungal compounds. British Journal of Dermatology 89, 509–14.CrossRefGoogle ScholarPubMed
Littman, M. C. & Miwitani, T. (1963). Effect of water soluble vitamins and their analogues on the growth of Candida albicans. I. Biotin, pyridoxamine, pyridoxine and fluorinated pyrimidines. Mycopathogia et mycologia applicata 21, 81108.CrossRefGoogle ScholarPubMed
Mareples, M. J. & Bailey, M. J. (1957). A march for the presence of pathogenic bacteria and fungi in the interdigital spaces of the foot. British Journal of Dermatology 69, 379–88.CrossRefGoogle Scholar
Miles, A. A. & Misra, S. S. (1938). Estimation of the bactericidal power of the blood. Journal of Hygiene 38, 732–9.Google ScholarPubMed
Minocha, Y., Pasricha, J. S., Mohapatra, L. N. & Kandhari, K. C. (1972). Proteolytic activity of dermatophytes and its role in the pathogenesis of skin lesions. Sabouraudia 10, 7985.CrossRefGoogle ScholarPubMed
Murphy, , Catherine, T. (1975). Nutrient materials and the growth of bacteria on human skin. Transactions of the St John's Hospital Dermatological Society 61, 51–7.Google ScholarPubMed
Noble, W. C. (1977). Variation in the prevalence of antibiotic resistance of Staphylococcus aureus from human skin and nares. Journal of General Microbiology 98, 125–32.CrossRefGoogle ScholarPubMed
Schönborn, C. (1968). Über Mischinfektionen bei Onychomykosen. Archiv für klinische und experimentelle Dermatologie 232, 115.CrossRefGoogle Scholar
Smith, J. M. B. & Marples, M. J. (1965). Dermatophyte infections in the hedgehog as a reservoir of penicillin-resistant staphylococci. Journal of Hygiene 63, 293303.CrossRefGoogle ScholarPubMed
Uri, J., Szatrmary, S. & Herpay, Zs. (1957 a). Production of antibiotic by dermatophytes living in horn products. Nature, London 179, 1029–30.CrossRefGoogle ScholarPubMed
Uri, J., Szathmary, S. & Herpay, Zs. (1957 b) Über die Antibioticaproduction von Pilzen am Ort ihres natürlichen Vorkommens. Die Pharmazie. 12, 485–8.Google Scholar
Wallerström, A. (1968). Production of antibiotics by dermatophyte fungi. 2. Microflora in Epidermophyton-infected skin and its resistance to antibiotics produced by the fungus. Acta pathologica et microbiologica scandinavica 74, 531–42.CrossRefGoogle Scholar
Youssef, N., Wyborn, C. H. E., Holt, C., Noble, W. C. & Clayton, Y. M. (1978). Antibiotic production by dermatophyte fungi. Journal of General Microbiology 105, 505–11.CrossRefGoogle ScholarPubMed