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Drug resistance rates of Mycobacterium tuberculosis strains in Austria between 1995 and 1998 and molecular typing of multidrug-resistant isolates

Published online by Cambridge University Press:  01 June 2000

F. STAUFFER ,
A. MAKRISTATHIS ,
J. P. KLEIN ,
W. BAROUSCH  and
The Austrian Drug Resistant Tuberculosis Study Group
F. STAUFFER
Affiliation:
National Reference Centre for Mycobacteria at the Federal Public Health Laboratory, Vienna, Austria
A. MAKRISTATHIS
Affiliation:
Department of Clinical Microbiology, Hygiene Institute of the University of Vienna, Austria
J. P. KLEIN
Affiliation:
Austrian Ministry of Labour, Health and Social Affairs
W. BAROUSCH
Affiliation:
Department of Clinical Microbiology, Hygiene Institute of the University of Vienna, Austria
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Abstract

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In this study the drug resistance pattern of 3559 Mycobacterium tuberculosis strains isolated in Austria between 1995 and 98 was evaluated. Of these strains, 165 (4·6%) were resistant to one or more drugs, 113 (3·2%) to one of the tested drugs and 53 (1·5%) to two or more drugs. Monodrug resistance was observed most often to isoniazid (56 strains), followed by streptomycin (44 strains). Resistance to rifampicin or ethambutol alone was rarely seen (12 strains and 1 strain, respectively). Of the 53 strains resistant to 2 or more drugs, 25 were resistant to isoniazid and streptomycin, while 17 were multidrug resistant. Molecular typing revealed a large diversity among the multidrug-resistant strains.

Type
Research Article
Information
Epidemiology & Infection , Volume 124 , Issue 3 , June 2000 , pp. 523 - 528
Copyright
© 2000 Cambridge University Press