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Dose–response effects in an outbreak of Salmonella enteritidis

Published online by Cambridge University Press:  15 May 2009

E. D. Mintz ,
M. L. Cartter ,
J. L. Hadler ,
J. T. Wassell ,
J. A. Zingeser  and
R. V. Tauxe
E. D. Mintz
Affiliation:
Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
M. L. Cartter
Affiliation:
Preventable Diseases Division, Connecticut State Department of Health Services
J. L. Hadler
Affiliation:
Preventable Diseases Division, Connecticut State Department of Health Services
J. T. Wassell
Affiliation:
Division of Surveillance and Epidemiology, Epidemiology Program Office, Centers for Disease Control and Prevention
J. A. Zingeser
Affiliation:
Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
R. V. Tauxe
Affiliation:
Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention
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The effects of ingested Salmonella enteritidis (SE) dose on incubation period and on the severity and duration of illness were estimated in a cohort of 169 persons who developed gastroenteritis after eating hollandaise sauce made from grade–A shell eggs. The cohort was divided into three groups based on self–reported dose of sauce ingested. As dose increased, median incubation period decreased (37 h in the low exposure group 21 h in the medium exposure group v. 17·5 h. in the high exposure group, P = 0.006) and greater proportions reported body aches (71 v. 85 v. 94%, P = 0.0009) and vomiting (21 v. 56 v. 57%, P = 0.002). Among 118 case-persons who completed a follow–up questionnaire, increased dose was associated with increases in median weight loss in kilograms (3.2 v. 4.5 v. 5.0, P = 0.0001), maximum daily number of stools (12.5 v. 15.0 v. 20.0, P = 0.02), subjective rating of illness severity (P = 0.0007), and the number of days of confinement to bed (3.0 v. 6.5, P = 0.04). In this outbreak, ingested dose was an important determinant of the incubation period, symptoms and severity of acute salmonellosis.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 1 , February 1994 , pp. 13 - 23
Copyright
Copyright © Cambridge University Press 1994

References

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