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Does chloramphenicol remain the drug of choice for typhoid?

Published online by Cambridge University Press:  19 October 2009

B. Rowe ,
E. J. Threlfall  and
L. R. Ward
B. Rowe
Affiliation:
WHO Collaborating Centre for Phage typing and Resistance of Enterbacteria, Division of Enteric Pathogens, Central Public Health Laboratory, 61, Colindale Avenue, London NW9 5HT
E. J. Threlfall
Affiliation:
WHO Collaborating Centre for Phage typing and Resistance of Enterbacteria, Division of Enteric Pathogens, Central Public Health Laboratory, 61, Colindale Avenue, London NW9 5HT
L. R. Ward
Affiliation:
WHO Collaborating Centre for Phage typing and Resistance of Enterbacteria, Division of Enteric Pathogens, Central Public Health Laboratory, 61, Colindale Avenue, London NW9 5HT
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Summary

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Of 2356 strains of Salmonella typhi isolated in Britain in the 8-year period 1978–85, 2345 (99·53%) were sensitive to all antibiotics tested and 11 (0·47%) were chloramphenicol-resistant; chloramphenicol resistance was plasmid-mediated in 6 strains. It is concluded that chloramphenicol remains a satisfactory first-line choice of drug for tyrphoid fever in Britain.

Type
Research Article
Information
Epidemiology & Infection , Volume 98 , Issue 3 , June 1987 , pp. 379 - 383
Copyright
Copyright © Cambridge University Press 1987

References

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