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The distribution of vaccinia virus, complement-fixing antigen and haemagglutinin throughout the egg after inoculation of the chorio-allantoic membrane

Published online by Cambridge University Press:  15 May 2009

Barbara M. Tobin
Barbara M. Tobin
Affiliation:
Department of Bacteriology, University of Manchester
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Vaccinia virus inoculated on the chorio-allantois and causing infection spread to the uninoculated part of the membrane, the embryo, the allantoic and amniotic fluids and the yolk within 1 day.

The virus grew in the embryo and possibly in the uninoculated part of the chorio-allantois, but in the latter no macroscopic lesions were detected.

Virus increased in amount in the allantoic fluid and may have grown in the lining of the allantoic sac; it did not increase in the amniotic fluid; it was present in yolk and increased slightly but its local growth was doubtful.

The presence of haemagglutinin and complement-fixing antigen was related to the amount of virus.

Allantoic fluid from infected eggs could be a ready source of antigen for complement-fixation.

Type
Research Article
Information
Journal of Hygiene , Volume 54 , Issue 1 , March 1956 , pp. 114 - 117
Copyright
Copyright © Cambridge University Press 1956

References

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