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Distribution of the meningococcal insertion sequence IS1301 in clonal lineages of Neisseria meningitidis

Published online by Cambridge University Press:  01 April 2000

R. HILSE ,
J. STOEVESANDT ,
D. A. CAUGANT ,
H. CLAUS ,
M. FROSCH  and
U. VOGEL
R. HILSE
Affiliation:
Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany Present address: Neurologische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
J. STOEVESANDT
Affiliation:
Institut für Hygiene und Mikrobiologie, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany
D. A. CAUGANT
Affiliation:
WHO Collaborating Centre for Reference and Research on Meningococci, National Institute of Public Health, P.O. Box 4404 Torshov, N-0403 Oslo, Norway
H. CLAUS
Affiliation:
Institut für Hygiene und Mikrobiologie, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany
M. FROSCH
Affiliation:
Institut für Hygiene und Mikrobiologie, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany
U. VOGEL
Affiliation:
Institut für Hygiene und Mikrobiologie, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany
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Abstract

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The distribution of the meningococcal insertion sequence IS1301 was analysed in 496 strains of different serogroups and clonal lineages of Neisseria meningitidis, and in 64 neisserial strains other than N. meningitidis. IS1301 was found in meningococci, but not in apathogenic Neisseria sp. and Neisseria gonorrhoeae. The copy numbers of IS1301 varied between 2 and 17 per genome. IS1301 positive strains were mostly found among the serogroups 29E, W135, X, and Y. Clonal lineages of serogroup A, B, and C meningococci associated with epidemic meningococcal disease were rarely positive for IS1301.

Type
SHORT PAPER
Information
Epidemiology & Infection , Volume 124 , Issue 2 , April 2000 , pp. 337 - 340
Copyright
© 2000 Cambridge University Press