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Distribution of immunity to pertussis in the population of England and Wales

Published online by Cambridge University Press:  19 October 2009

P. E. M. Fine  and
J. A. Clarkson
P. E. M. Fine
Affiliation:
Ross Institute, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
J. A. Clarkson
Affiliation:
Ross Institute, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Summary

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This paper presents three different methods of estimating the number and age distribution of individuals susceptible to pertussis in England and Wales. The first approach is an extrapolation from data in the prevaccine era, the second is based upon theoretical consideration of the transmission dynamics of pertussis, and the third is a detailed cohort analysis of available notification and vaccination data. Each of these analyses suggests that the total number of people susceptible to pertussis infection in England and Wales has remained at 3–4 million for the past 40 years, despite the increase and changes in numbers vaccinated. The effect of vaccination has been to reduce the incidence of infection and disease, but not to reduce the number of susceptibles. These findings, which are consistent with ‘mass action theory’, could be tested by an appropriately designed seroepidemiological survey.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 1 , February 1984 , pp. 21 - 36
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Anderson, R. M. & May, R. M. (1982). Directly transmitted infectious diseases: control by vaccination. Science 215 1053–1060.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1983). Vaccination against rubella and measles: quantitative investigations of different policies. Journal of Hygiene 90, 259–325.CrossRefGoogle ScholarPubMed
Bassili, W. R. & Stewart, G. T. (1976). Epidemiological evaluation of immunisation and other factors in the control of whooping-cough. Lancet i, 471–474.CrossRefGoogle Scholar
Bordet, J. & Gengou, O. (1906). Le microbe de la coqueluche. Annales de l'lnstitut Pasteur, Paris 20, 731–741.Google Scholar
Bordet, J. & Gengou, O. (1907). Note complémentaire sur le microbe de la coqueluche. Annales de l'lnstitut Pasteur, Paris 21, 720–726.Google Scholar
Bradstreet, C. M. P., Tannahill, A. J., Edwards, J. M. B. & Benson, P. F. (1972). Detection of Bordetella pertussis antibodies in human sera by complement-fixation and immunofluorescence. Journal of Hygiene 70, 75–83.CrossRefGoogle ScholarPubMed
Broome, C. V., Fraser, D. W. & English, W. J. (1970). Pertussis – diagnostic methods and surveillance. In International Symposium on Pertussis, 1978 (ed. Manclark, C. R. and Hill, J. C.), pp. 19–22. Washington, D.C.: Department of Health Education and Welfare, Public Health Service, 1979.Google Scholar
Broome, C. V., Preblud, S. R., Bruner, B., McGowan, J. E., Hayes, P. S., Harris, P. P., Elsea, W. & Fraser, D. W. (1981). Epidemiology of pertussis, Atlanta, 1977. Journal of Pediatrics 98, 362–367.CrossRefGoogle ScholarPubMed
Clarkson, J. A. & Fine, P. E. M. (1984). The efficiency of measles and pertussis morbidity reporting in England and Wales. (submitted.)Google Scholar
Collins, S. D. (1929). Age incidence of the common communicable diseases of children. Public Health Reports 44, 763–826.CrossRefGoogle Scholar
Dietz, K. (1974). Transmission and control of arbovirus diseases. In Proceedings of the SIMS Conference on Epidemiology Held at Alta, Utah, 8–12 07 1974. SIAM-SIMS Conference Series, no. 21 (ed. Ludwig, D. and Cook, K. L.), pp. 104–121. Philadelphia: Society for Industrial-Applied Mathematics.Google Scholar
Fine, P. E. M. & Clarkson, J. A. (1982 a). Measles in England and Wales. II. The impact of the measles vaccination programme on the distribution of immunity in the population. International Journal of Epidemiology 11, 15–25.CrossRefGoogle ScholarPubMed
Fine, P. E. M. & Clarkson, J. A. (1982 b). The recurrence of whooping-cough: possible implications for assessment of vaccine efficacy. Lancet i, 666–669.CrossRefGoogle Scholar
Gordon, J. E. & Hood, R. I. (1951). Whooping-cough and its epidemiological anomalies. American Journal of the Medical Sciences 222, 333–361.CrossRefGoogle ScholarPubMed
Granstrom, M., Lindrerg, A. A., Askelof, P. & Hederstedt, B. (1982). Detection of antibodies in human sera against the fimbrial haemagglutinin of Bordetella petussis by enzyme-linked immunological assay. Journal of Medical Microbiology 15, 85–96.CrossRefGoogle Scholar
Griffith, A. H. (1979). Development of the pertussis vaccination programme in England and Wales and its effects on whooping-cough morbidity and mortality. In International Symposium on Immunisation: Benefit versus Bisk Factors, Brussels, 1978. Develop. Biol. Standard 43, 91–94. Basel: S. KargerGoogle Scholar
Kendrick, P. L., Gottshall, R. Y., Anderson, H. D., Volk, V. K., Bunney, W. E. & Top, F. H. (1969). Pertussis agglutinins in adults. Public Health Reports 84, 9–15.CrossRefGoogle ScholarPubMed
Lambert, H. J. (1965). Epidemiology of a small pertussis outbreak in Kent County, Michigan. Public Health Reports 80, 365–369.CrossRefGoogle ScholarPubMed
Linneman, C. C. (1979). Host–parasite interactions in pertussis. In International Symposium on Pertussis 1978 (ed. Manclark, C. R. and Hill, J. C.), pp. 3–18. Washington, D.C.: Department of Health Education and Welfare, Public Health Service.Google Scholar
Macaulay, M. E. (1979). The serological diagnosis of whooping-cough. Journal of Hygiene 83, 95–102.CrossRefGoogle ScholarPubMed
Miller, C. L. & Fletcher, W. B. (1976). Severity of notified whooping-cough. British Medical Journal i, 117–119.CrossRefGoogle Scholar
Miller, J. J., Silverberg, R. J., Saito, T. M. & Humber, J. B. (1943). An agglutination reaction for Hemophilus pertussis. II. Its relation to clinical immunity. Journal of Pediatrics 22, 644–652.CrossRefGoogle Scholar
Morse, S. I. (1968). Pertussis in adults. Annals of Internal Medicine 68, 953–954.CrossRefGoogle ScholarPubMed
Office of Population Censuses and Surveys (1974–1980 a). Statistics of Infectious Diseases. London: HMSO.Google Scholar
Office of Population Censuses and Surveys (1957–1978 b). Hospital In-patient Enquiry. London: HMSO.Google Scholar
Pittman, M. (1979). Pertussis toxin: The cause of the harmful effects and prolonged immunity of whooping-cough. Review of Infectious Disesases 1, 401–412.CrossRefGoogle ScholarPubMed
Public Health Laboratory Service (1969). Efficacy of whooping-cough vaccines used in the United Kingdom before 1968. British Medical Journal iv, 329–333.Google Scholar
Public Health Laboratory Service (1970). Diagnosis of whooping-cough comparison of serological tests with isolation of Bordetella pertussis. A combined Scottish study. British Medical Journal iv, 637–639.Google Scholar
Public Health Laboratory Service Epidemiologioal Research Laboratory (1982). Efficacy of pertussis vaccination in England. British Medical Journal 285, 357–359.Google Scholar
Registrar General (1940–1973). Annual Review of the Registrar General of England and Wales. London: HMSO.Google Scholar
Stocks, P. (1933). Some epidemiological features of whooping-cough – A statistical investigation. Lancet i, 213–216, 265–269.CrossRefGoogle Scholar
Sydenstricker, E. (1932). Effect of a whooping-cough epidemic upon the size of the non-immune group in an urban community. Quarterly Bulletin of the Milbank Memorial Fund 10, 302–314.CrossRefGoogle Scholar
Wardlaw, A. C. & Parton, R. (1983). Pertussis vaccine. In Medical Microbiology (ed. Jeljaszewicz, J. and Easmon, C. S. F.), vol. II. Academic Press.Google Scholar
Williams, W. O. (1981). Whooping-cough in adults. British Medical Journal 283, 1122.CrossRefGoogle ScholarPubMed