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The development and use of a test to identify resistance to the anticoagulant difenacoum in the Norway rat (Rattus norvegicus)*

Published online by Cambridge University Press:  15 May 2009

R. Redfern
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surbiton, Surrey
J. E. Gill
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surbiton, Surrey
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Summary

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Feeding tests were carried out in the laboratory to obtain basic data on the susceptibility of wild Norway rats to difenacoum. The results were used to derive a standard test procedure for the identification of difenacoum resistance in warfarin-susceptible and resistant rats. Details are given of tests on rats from suspected difenacoum-resistant infestations on farms.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Boyle, C. M. (1960). Case of apparent resistance of Rattus norvegicus Berkenhout to anticoagulant poisons. Nature, London 188, 517.CrossRefGoogle Scholar
Drummond, D. C. & Wilson, E. J. (1968). Laboratory investigations of resistance to warfarin of Rattus norvegicus Berk, in Montgomeryshire and Shropshire. Annals of Applied Biology 61, 303–12.Google ScholarPubMed
Finney, D. J. (1971). Probit Analysis. 3rd ed.Cambridge University Press.Google Scholar
Greaves, J. H. & Ayres, P. B. (1969). Some rodenticidal properties of coumatetralyl. Journal of Hygiene 67, 311–15.CrossRefGoogle ScholarPubMed
Greaves, J. H., Rennison, B. D. & Redfern, R. (1973). Warfarin resistance in the ship rat in Liverpool. International Pest Control 15 (2), 17.Google Scholar
Hadler, M. R., Redfern, R. & Rowe, F. P. (1975). Laboratory evaluation of difenacoum as a rodenticide. Journal of Hygiene 74, 441–8.CrossRefGoogle ScholarPubMed
Litchfield, J. T. & Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96, 99113.Google ScholarPubMed
Rennison, B. D. & Hadler, M. R. (1975). Field trials of difenacoum against warfarin-resistant infestations of Rattus norvegicus. Journal of Hygiene 74, 449–55.CrossRefGoogle ScholarPubMed
Rowe, F. P. & Redfern, R. (1965). Toxicity tests on suspected warfarin-resistant house mice (Mus musculus L.). Journal of Hygiene 63, 417–25.CrossRefGoogle ScholarPubMed
Rowe, F. P. & Redfern, R. (1968). Comparative toxicity of the two anticoagulants, coumatetralyl and warfarin to wild house mice (Mus musculus L.). Annals of Applied Biology 62, 355–61.CrossRefGoogle ScholarPubMed
World Health Organization (1975). Instructions for determining the susceptibility or resistance of rodents to anticoagulant rodenticides. W.H.O./V.B.C./75.595.Google Scholar