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Corynebacterium kutscheri and its alleged avirulent variant in mice

Published online by Cambridge University Press:  15 May 2009

R. G. Hirst  and
R. J. Olds
R. G. Hirst
Affiliation:
Department of Pathology, University of Cambridge
R. J. Olds
Affiliation:
Department of Pathology, University of Cambridge
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Summary

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Corynebacterium kutscheri and its alleged avirulent variant were re-examined in C57Bl/6 and Swiss Lynch mice. It was confirmed that while C57B1/6 mice were resistant and Swiss Lynch susceptible to C. kutscheri, the alleged atypical variant was avirulent in both mouse strains. However, following inimunosuppression of C57B1/6 mice with hydrocortisone acetate, it was not possible to reactivate latent C. kutscheri or the alleged atypical variant; this was contrary to previous reports. Moreover, sequential hysterectomy derivation over four generations of C57B1/6 mice did not eliminate their resistance to C. kutscheri compared with conventionally born animals. Vaccination with live attenuated C. kutscheri protected susceptible mice against virulent challenge; vaccination with the alleged atypical variant afforded no such protection. The suggested role of the alleged avirulent variant in resistance to C. kutscheri is challenged and an alternative explanation of such resistance is proposed.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 3 , June 1978 , pp. 349 - 356
Copyright
Copyright © Cambridge University Press 1978

References

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