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A controlled trial of inactivated monovalent influenza A vaccines in general practice

Published online by Cambridge University Press:  15 May 2009

Hélène J. Mair ,
D. A. W. Sansome  and
Hilary E. Tillett
Hélène J. Mair
Affiliation:
Public Health Laboratory Service, Groby Road Hospital, Groby Road, Leicester LE3 9QE
D. A. W. Sansome
Affiliation:
Braunstone, Leicester
Hilary E. Tillett
Affiliation:
Epidemiological Research Laboratory, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
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Summary

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A trial of influenza A vaccines in general practice is described. Five hundred and seven subjects were vaccinated with either inactivated monovalent A/Hong Kong vaccine, A/England vaccine or influenza B vaccine as control. Local reactions were noted in 24% and general reactions in 12% of patients. Antibody titres in serum were measured by haemagglutination inhibition (HI) and complement fixation (CF) tests in 465 subjects. The influenza vaccines produced substantial increases in both homologous and heterologous antibodies as measured by the HI test and a comparatively poor response as measured by the CF test. Although clinical influenza was confirmed in only a few cases, there was serological evidence of significant subclinical infection in the control group.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 2 , October 1974 , pp. 317 - 327
Copyright
Copyright © Cambridge University Press 1974

References

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