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A controlled estimate of the risk of HIV infection in Ethiopian children with tuberculosis

Published online by Cambridge University Press:  05 February 2002

I. BERGGREN PALME ,
B. GUDETTA ,
H. DEGEFU ,
L. MUHE ,
J. BRUCHFELD  and
J. GIESECKE
I. BERGGREN PALME
Affiliation:
Department of Infectious Diseases, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden Unit for Infectious Disease Epidemiology, Microbiological and Tumour Biology Centre, Karolinska Institutet, Stockholm, Sweden
B. GUDETTA
Affiliation:
Ethio-Swedish Children’s Hospital, Department of Paediatrics, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
H. DEGEFU
Affiliation:
Ethio-Swedish Children’s Hospital, Department of Paediatrics, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
L. MUHE
Affiliation:
Ethio-Swedish Children’s Hospital, Department of Paediatrics, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
J. BRUCHFELD
Affiliation:
Department of Infectious Diseases, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
J. GIESECKE
Affiliation:
Unit for Infectious Disease Epidemiology, Microbiological and Tumour Biology Centre, Karolinska Institutet, Stockholm, Sweden
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Abstract

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To quantify the risk of human immunodeficiency virus (HIV) infection in children with tuberculosis (TB) a hospital-based, 1-year prospective, case-control study was performed in Addis Ababa, Ethiopia. Children with TB were compared to a control group of children admitted for elective surgery. The control group was also compared to a recent census of the background population. The crude odds ratio for HIV infection was 8·6 (95% CI 2·2–73). After adjustment for possible confounders in a multivariate regression model, the odds ratio for HIV infection in children with TB was found to be 12·7 (95% CI 2·9–55). Of several independent determinants of TB assessed in the study, this association was the strongest. Until HIV transmission has reached its peak, an increasing burden of dual infection among Ethiopian children is to be expected.

Type
Research Article
Information
Epidemiology & Infection , Volume 127 , Issue 3 , December 2001 , pp. 517 - 525
Copyright
2001 Cambridge University Press