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Control at hospital level of infections by methicillin-resistant staphylococci in children

Published online by Cambridge University Press:  15 May 2009

M. F. Michel  and
Catharina C. Priem
M. F. Michel
Affiliation:
Department of Bacteriology, Sophia Children's Hospital and Neonatal Unit, Academical Hospital, Medical Faculty Rotterdam, 160 Gordelweg, Rotterdam 4, The Netherlands
Catharina C. Priem
Affiliation:
Department of Bacteriology, Sophia Children's Hospital and Neonatal Unit, Academical Hospital, Medical Faculty Rotterdam, 160 Gordelweg, Rotterdam 4, The Netherlands
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Rapid spread of methicillin-resistant staphylococci (MeRS) in a children's hospital is described. Within 4 months of the first isolation MeRS had been isolated from infections in all clinical units. MeRS were also regularly isolated at the out-patient department. Protective isolation of one of the clinical units had no effect on the infection rate by MeRS. The use of antiseptics (Hexachlorophene and chlorhexidine) and gentamicin nose cream in children and staff members in three out of five clinical units resulted in a significant reduction of the prevalence of nose colonization by MeRS in children. In staff members a non-significant reduction of the prevalence of colonization and a significant reduction of the acquisition of MeRS was found. After a few months the infection rate decreased to zero in the units where the measures were introduced. It remained unchanged in the other units. Phage typing of two sets of strains collected at an interval of 6 months showed that the infections were mainly caused by two endemic strains of MeRS. The majority of the infections caused by MeRS was of minor importance. In 16 % of the infections a strain was isolated repeatedly and for more than 1 week. After the introduction of antiseptics a relative increase of infections by Gram-negative bacteria was observed. The significance of this phenomenon is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 3 , September 1971 , pp. 453 - 460
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Annear, D. I. (1968). The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibiotics. Medical Journal of Australia i, 444.CrossRefGoogle Scholar
Baber, K. G., Corner, B., Duncan, E. H. L., Eades, S. M., Gillespie, W. A. & Walker, S. C. B. (1967). A prospective study of staphylococcal infection and its prevention among infants and mothers after childbirth in hospital and at home. Journal of Hygiene 65, 381.CrossRefGoogle ScholarPubMed
Barber, M. (1961). Methicillin-resistant staphylococci. Journal of Clinical Pathology 14, 385.CrossRefGoogle ScholarPubMed
Barber, M. (1964). Naturally occurring methicillin-resistant staphylococci. Journal of General Microbiology 35, 183.CrossRefGoogle ScholarPubMed
Barrett, F. F., McGehee, R. G. & Finland, M. (1968). Methicillin-resistant Staphylococcus aureus at Boston city hospital. New England Journal of Medicine 279, 441.CrossRefGoogle ScholarPubMed
Benner, E. J. & Kayser, F. H. (1968). Growing clinical significance of methicillin-resistant Staphylococcus aureus. Lancet ii, 742.Google Scholar
Cetin, E. T. & Ang, Ö. (1962). Staphylococci resistant to methicillin (‘celbenin’). British Medical Journal ii, 51.CrossRefGoogle Scholar
Chabbert, Y. A. & Baudens, J. G. (1962). Souches de staphylocoques résistant naturellement à la méthicilline et à la 5-methyl-3-phényl-9-iso-oxazolyl-penicilline (P 12). Annales de l' Institut Pasteur 103, 222.Google Scholar
Chabbert, Y. A., Baudens, J. G., Acar, J. F. & Gerbaud, G. R. (1965). La résistance naturelle des staphylocoques à la méthicilline et l'oxacilline. Revue française d'études cliniques et biologiques 10, 495.Google Scholar
Chabbert, Y. A. & Pillet, J. (1967). Correlation between ‘methicillin resistance’ and serotype in Staphylococcus. Nature, London 213, 1137.CrossRefGoogle ScholarPubMed
Colley, E. W., McNicol, M. W. & Bracken, J. M. (1965). Methicillin-resistant Staphylococci in a general hospital. Lancet i, 595.CrossRefGoogle Scholar
Conn, N. K. (1969). Coliform bacteriaemia in infants. Scottish Medical Journal 14, 23.CrossRefGoogle Scholar
Courtieu, A. L., Guillermet, F. N., Longeray, C., Maka, G. & Chabbert, Y. A. (1964). Fréquence des staphylocoques présentant une résistance hétèrogéne à la méthicilline et l'oxacilline en milieu hospitalier. Annales de l' Institut Pasteur 107, 691.Google Scholar
Dyke, K. G. H., Jevons, M. & Parker, M. T. (1966). Penicillinase production and intrinsic resistance to penicillins in Staphylococcus aureus. Lancet i, 835.CrossRefGoogle Scholar
Forfar, J. O., Gould, J. C. & Maccabe, A. F. (1968). Effect of hexachlorophane on incidence of staphylococcal and Gram-negative infection in the newborn. Lancet ii, 177.CrossRefGoogle Scholar
Gillespie, W. A., Simpson, K. & Tozer, R. C. (1958). Staphylococcal infection in a maternity hospital. Lancet ii, 1075.CrossRefGoogle Scholar
Jessen, O., Rosendal, K., Bülow, P., Faber, V. & Eriksen, K. R. (1969). Changing Staphylococci and staphylococcal infections. New England Journal of Medicine 281, 627.CrossRefGoogle ScholarPubMed
Jevons, M. P. (1961). ‘Celbenin’-resistant Staphylococci. British Medical Journal i, 124.CrossRefGoogle Scholar
Knox, R. (1961). ‘Celbenin’-resistant Staphylococci. British Medical Journal i, 126.CrossRefGoogle Scholar
Knox, R. & Smith, J. T. (1961). Nature of penicillin resistance in Staphylococci. Lancet ii, 520.CrossRefGoogle Scholar
Light, I. J., Sutherland, J. M., Cockran, M. L. & Sutorius, J. (1968). Ecologic relation between Staphylococcus aureus and pseudomonas in a nursery population. New England Journal of Medicine 278, 1243.CrossRefGoogle Scholar
Mouton, R. P. & van Boven, C. P. (1969). Letter to the editor. Nederlands Tijdschrift voor Geneeskunde 113, 131.Google Scholar
O'Toole, R. D., Drew, W. L., Dahlgren, B. J. & Beaty, H. N. (1970). An outbreak of methicillin-resistant Staphylococcus aureus infection. Journal of the American Medical Association 213, 257.CrossRefGoogle ScholarPubMed
Parker, M. T. & Hewitt, J. H. (1970). Methicillin resistance in Staphylococcus aureus. Lancet i, 800.CrossRefGoogle Scholar
Rountree, P. M. & Beard, M. A. (1968). Hospital strains of Staphylococcus aureus, with particular reference to methicillin-resistant strains. Medical Journal of Australia i, 1163.CrossRefGoogle Scholar
Sabbath, L. D., Leaf, C. D., Gerstein, P. A. & Finland, M. (1970). Altered cell walls of Staphylococcus aureus resistant to methicillin. Nature, London 225, 1074.CrossRefGoogle Scholar
Shooter, R. A. (1965). In Skin Bacteria and their Role in Infection, ed. Maibach, H. I. and Hildick-Smith, G.. New York: McGraw-Hill.Google Scholar
Stewart, G. T. & Holt, R. J. (1963). Evolution of natural resistance to the newer penicillins. British Medical Journal i, 308.CrossRefGoogle Scholar
Sutherland, R. & Rolinson, G. N. (1964). Characteristics of methicillin-resistant Staphylococci. Journal of Bacteriology 87, 887.CrossRefGoogle ScholarPubMed
Williams, R. E. O., Blowers, R., Garrod, L. P. & Shooter, R. A. (1966). In Hospital Infection, Causes and Prevention. London: Lloyd-Luke.Google Scholar