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A Contribution to the Problem of the Virulence (“VI”) Antigen of B. typhosus1

Published online by Cambridge University Press:  15 May 2009

S. S. Dyachenko
S. S. Dyachenko
Affiliation:
From the Microbiological Department (chief Prof. M. P. Neshtchadimenko) of the Bacteriological Institute of Kiev(Dir. Dr A. M. Luchin)
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Summary

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1. The strains of B. typhosus, which are inagglutinable, or non-sensitive to somatic O agglutinins, are virulent, whereas the agglutinable, or sensitive strains, show a low virulence.

2. Virulence and inagglutinability of strains seem to depend upon the presence in them of a virulence (Vi) antigen.

3. A considerable protective action, observed by means of active and passive immunisation, is exerted by the inagglutinable strain used (205 D), because it contains Vi antigen.

4. When the O and H agglutinins are eliminated through absorption, the agglutination reaction may serve to demonstrate in vitro the presence of the Vi antibody.

Type
Research Article
Information
Journal of Hygiene , Volume 36 , Issue 1 , February 1936 , pp. 108 - 113
Copyright
Copyright © Cambridge University Press 1936

References

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