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Contribution of second stool specimen to increased sensitivity of poliovirus detection in India, 1998–2000

Published online by Cambridge University Press:  23 September 2003

K. A. KOHLER ,
J. M. DESHPANDE ,
H. E. GARY ,
K. BANERJEE ,
P. L. F. ZUBER  and
W. G. HLADY
K. A. KOHLER
Affiliation:
Global Immunization Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
J. M. DESHPANDE
Affiliation:
Enterovirus Research Centre, Indian Council of Medical Research, Mumbai, India
H. E. GARY
Affiliation:
Global Immunization Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
K. BANERJEE
Affiliation:
National Polio Surveillance Project, World Health Organization, New Delhi, India World Health Organization, Southeast Asia Regional Office, New Delhi, India
P. L. F. ZUBER
Affiliation:
Global Immunization Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
W. G. HLADY
Affiliation:
National Polio Surveillance Project, World Health Organization, New Delhi, India
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Abstract

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Acute flaccid paralysis (AFP) surveillance data from India were analysed to examine sensitivity of poliovirus isolation from stool specimens and the added sensitivity obtained from collection of a second stool specimen. Analysis was restricted to Indian AFP cases, 1998–2000, with two adequate stool specimens. The proportion of cases confirmed with wild poliovirus isolation by the second specimen only was calculated, regardless of specimen quality. Overall specimen sensitivity (1998–2000) was 81% using the first specimen, 78% using the second, and 96% using both. Sensitivity increased from 1998 to 2000, with slightly higher sensitivity each year for the first specimen. The second specimen increased sensitivity by 15% overall and contributed more when the first specimen was collected late or was in poor condition. As wild poliovirus disappears, increased sensitivity provided by a second stool specimen may reduce the risk of missing circulating virus.

Type
Research Article
Information
Epidemiology & Infection , Volume 131 , Issue 1 , August 2003 , pp. 711 - 718
Copyright
© 2003 Cambridge University Press