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Contaminant viruses in two live virus vaccines produced in chick cells

Published online by Cambridge University Press:  15 May 2009

R. J. C. Harris ,
R. M. Dougherty ,
P. M. Biggs ,
L. N. Payne ,
A. P. Goffe ,
A. E. Churchill  and
R. Mortimer
R. J. C. Harris
Affiliation:
Division of Experimental Biology and Virology Imperial Cancer Research Fund, London, N. W. 7
R. M. Dougherty
Affiliation:
Division of Experimental Biology and Virology Imperial Cancer Research Fund, London, N. W. 7
P. M. Biggs
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon
L. N. Payne
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon
A. P. Goffe
Affiliation:
Department of Virology, Wellcome Research Laboratories, Beckenham, Kent
A. E. Churchill
Affiliation:
Department of Virology, Wellcome Research Laboratories, Beckenham, Kent
R. Mortimer
Affiliation:
R.A.F. Institute of Pathology and Tropical Medicine, Halton, Bucks
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Samples of yellow-fever vaccine prepared from homogenized chick embryos, and of an experimental measles vaccine prepared from chick embryo cells, have each been shown to contain a contaminant virus similar in properties to an avian leukosis virus. Young adult males injected with the yellow-fever vaccine did not develop neutralizing antibodies for Rous sarcoma virus.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 1 , March 1966 , pp. 1 - 7
Copyright
Copyright © Cambridge University Press 1966

References

REFERENCES

Benson, P. F., Butler, N. R., Goffe, A. P., Knight, G. J., Laurence, G. D., Miller, C. L. & Pollock, T. M. (1964). Vaccination of infants with living attenuated measles vaccine (Edmonston strain) with and without gamma-globulin. Br. med. J. ii, 851–3.CrossRefGoogle Scholar
Biggs, P. M. & Payne, L. N. (1965). Relationship of Marek's disease (neural lymphomatosis) to lymphoid leukosis. J. natn. Cancer Inst, monograph no. 17, pp. 83–98.Google Scholar
Eddy, B. E., Borman, G. S., Berkeley, W. H. & Young, R. D. (1961). Tumors induced in hamsters by injection of Rhesus monkey kidney cell extracts. Proc. Soc. exp. Biol. Med. 107, 191–7.CrossRefGoogle ScholarPubMed
Fox, J. P., Kossobudzki, S. L. & da Cunha, J. F. (1943). Field studies on the immune response to 17 D yellow fever virus. Relation to virus substrain, dose and route of inoculation. Am. J. Hyg. 38, 113–38.Google Scholar
Girardi, A. J., Sweet, B. H., Slotnick, V. B. & Hilleman, M. R. (1962). Development of tumors in hamsters inoculated in the neonatal period with vacuolating virus, SV40. Proc. Soc. exp. Biol. Med. 109, 649–60.CrossRefGoogle Scholar
Goffe, A. P. & Laurence, G. D. (1961). Vaccination against measles. Part I. Preparation and testing of vaccines consisting of living attenuated virus. Br. med. J. ii, 1244–6.CrossRefGoogle Scholar
Hanafusa, H., Hanafusa, T. & Rubin, H. (1964). Analysis of the defectiveness of Rous sarcoma virus. II. Specification of RSV antigenicity by helper virus. Proc. natn. Acad. Sci. U.S.A. 51, 41–8.CrossRefGoogle ScholarPubMed
Jensen, F. C, Girardi, A. J., Gilden, R. V. & Koprowski, H. (1964). Infection of human and simian tissue cultures with Rous sarcoma virus. Proc. natn. Acad. Sci. U.S.A. 52, 53–9.CrossRefGoogle ScholarPubMed
Munroe, J. S. & Windle, W. F. (1963). Tumors induced in primates by chicken sarcoma virus. Science, 140, 1415–16.CrossRefGoogle ScholarPubMed
Nichols, W. W., Levan, A., Coriell, L. L., Goldner, H. & Ahlström, C. G. (1964). Chromosome abnormalities in vitro in human leucocytes associated with Schmidt-Ruppin Rous sarcoma virus. Science, 146, 248–50.CrossRefGoogle ScholarPubMed
Rubin, H. (1960). A virus in chick embryos which induces resistance in vitro to infection with Rous sarcoma virus. Proc. natn. Acad. Sci. U.S.A. 46, 1105–19.CrossRefGoogle ScholarPubMed
Simons, P. J. & Dougherty, R. M. (1963). Antigenic characteristics of three variants of Rous sarcoma virus. J. natn. Cancer Inst. 31, 1275–83.Google ScholarPubMed
Watson, G. I. (1965). Studies on killed and attenuated measles vaccine in general practice. Br. med. J. ii, 13–16.CrossRefGoogle Scholar