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The conglutination phenomenon. III. The conglutinating complement absorption test in experimental glanders

Published online by Cambridge University Press:  15 May 2009

N. H. Hole  and
R. R. A. Coombs
N. H. Hole
Affiliation:
From the Veterinary Laboratory, Ministry of Agriculture and Fisheries, Weybridge, and The Department of Pathology, University of Cambridge
R. R. A. Coombs
Affiliation:
From the Veterinary Laboratory, Ministry of Agriculture and Fisheries, Weybridge, and The Department of Pathology, University of Cambridge
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1. Observations on the sera of ponies, taken at frequent intervals for 321 days after oral administration of P. mallei, are described.

2. It was found that the conglutinating complement absorption test was more sensitive than the haemolytic complement fixation test as a means of diagnosis. It detected the antibodies earlier in the course of the disease and demonstrated their presence over a longer period of time.

3. The possibility of another practical use of this reaction as an adjunct to the allergic test is considered. Ten days after an intradermo-palpebral test a pony, which had been previously sensitized and whose serum antibody titre at that time was below 10, developed a serum titre of over 160 as demonstrated by the conglutinating complement absorption test. Under similar circumstances 11 unsensitized ponies developed no detectable serum antibodies.

Type
Research Article
Information
Journal of Hygiene , Volume 45 , Issue 4 , December 1947 , pp. 497 - 503
Copyright
Copyright © Cambridge University Press 1947

References

REFERENCES

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