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Comparison of the immunogenicity, efficacy and safety of 10 μg and 20 μg of a hepatitis B vaccine: a prospective randomized trial

Published online by Cambridge University Press:  19 October 2009

E. K. Yeoh ,
C. L. Lai ,
W. K. Chang  and
H. Y. Lo
E. K. Yeoh
Affiliation:
Queen Elizabeth Hospital, Hong Kong
C. L. Lai
Affiliation:
University Department of Medicine, Queen Mary Hospital, Hong Kong
W. K. Chang
Affiliation:
Virus Unit, Medical and Health Department, Hong Kong
H. Y. Lo
Affiliation:
Queen Elizabeth Hospital, Hong Kong
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Four thousand and one hospital staff were screened for hepatitis B virus (HBV) markers in a vaccination programme in Hong Kong. The seropositivity rate for HBsAg, anti-HBs and anti-HBc were significantly higher in the 3160 existing hospital staff than in 841 new recruits. Of the subjects negative for HBV markers, 605 were randomized to receive three doses of either 10 or 20 μg of the Merck Institute vaccine (HB-VAX). Compared with the 20 μg dose, vaccination with the 10 μg dose results in equal immunogenicity and efficacy at the completion of the three injections but induced a slower response rate and lower anti-HBs titres with the first two doses. The commonest side-effect of local soreness was less with the 10 μg dose. We conclude that (1) hospital staff working in high endemic areas should be vaccinated on recruitment and (2) the 10 μg dose of HB-VAX can replace the recommended 20 μg dose for adults, being cheaper and as efficacious.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 491 - 499
Copyright
Copyright © Cambridge University Press 1986

References

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