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A comparison of methods of measuring the persistence of neutralizing and haemagglutinin-inhibiting antibodies to louping ill virus in experimentally infected sheep

Published online by Cambridge University Press:  15 May 2009

K. J. O'Reilly ,
C. E. Gordon Smith ,
D. A. McMahon ,
E. T. W. Bowen  and
G. White
K. J. O'Reilly
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent
C. E. Gordon Smith
Affiliation:
Microbiological Research Establishment, Salisbury, Wilts.
D. A. McMahon
Affiliation:
Microbiological Research Establishment, Salisbury, Wilts.
E. T. W. Bowen
Affiliation:
Microbiological Research Establishment, Salisbury, Wilts.
G. White
Affiliation:
Wellcome Veterinary Research Station, Frant
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Sheep, after infection with louping ill virus and after re-infection with the same strain of virus 19–21 months later, were bled at intervals and their sera examined for neutralizing and haemagglutinin-inhibiting antibodies. Each antibody type was measured by the constant serum/variable virus and constant virus/variable serum methods. The persistence of each type of antibody and its significance in epidemiological studies is discussed. The relationship of antibody levels in ewes and their lambs was also examined.

Type
Original Articles
Information
Journal of Hygiene , Volume 66 , Issue 2 , June 1968 , pp. 217 - 227
Copyright
Copyright © Cambridge University Press 1968

References

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