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A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

Published online by Cambridge University Press:  15 May 2009

A. Clark ,
C. W. Potter ,
R. Jennings ,
J. P. Nicholl ,
A. F. Langrick ,
G. C. Schild ,
J. M. Wood  and
D. A. J. Tyrrell
A. Clark
Affiliation:
Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX
C. W. Potter
Affiliation:
Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX
R. Jennings
Affiliation:
Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX
J. P. Nicholl
Affiliation:
Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX
A. F. Langrick
Affiliation:
Health Centre, University of Birmingham, Birmingham, B15 2TJ
G. C. Schild
Affiliation:
Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB
J. M. Wood
Affiliation:
Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB
D. A. J. Tyrrell
Affiliation:
Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ
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Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 3 , June 1983 , pp. 351 - 359
Copyright
Copyright © Cambridge University Press 1983

References

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