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Comparison of antibody responses and virus shedding following administration of trivalent oral poliomyelitis vaccines prepared either in monkey kidney or human diploid cell substrates

Published online by Cambridge University Press:  15 May 2009

D. S. Freestone ,
A. Kelly ,
R. Ferris ,
R. L. L. Simmons ,
C. Bowkerj ,
E. Letley  and
C. Bye
D. S. Freestone
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
A. Kelly
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
R. Ferris
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
R. L. L. Simmons
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
C. Bowkerj
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
E. Letley
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
C. Bye
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
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Summary

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Nineteen (22·9%) of 83 sera collected before vaccination from adult volunteers aged 21–64 years were without neutralizing antibody to poliomyeitis at levels of 0·15 i.u./ml for types I and II and 0·1 i.u./ml for type III. Some correlations were found between the history of previous vaccination and the presence of antibody but these were not well defined.

Vaccination with a single dose of trivalent oral polio vaccine elicited fourfold or greater antibody responses to one or more poliomyelitis types in 53 (63·9%) volunteers, the percentage antibody responses being inversely related to the titre of antibody present before vaccination. Types I, II or III poliomyelitis virus were recovered from 76·8 % of faecal samples collected 1 week after vaccination. The percentage recovery progressively declined thereafter until virus was recovered from 10·5 % of samples collected 6 weeks after vaccination.

Type for type, the titres and percentages of antibody responses and virus shedding in faeces were similar following trivalent oral poliomyelitis vaccines whether prepared in monkey kidney or human diploid cell substrates. Some change in reproductive capacity temperature (r.c.t./40) marker was found in faecal isolates from volunteers vaccinated with monkey kidney and human diploid grown vaccines but no change in ‘d’ marker was found.

Type
Research Article
Information
Journal of Hygiene , Volume 84 , Issue 1 , February 1980 , pp. 17 - 28
Copyright
Copyright © Cambridge University Press 1980

References

REFERENCES

Beale, A. J. (1969). Immunization against poliomyelitis. British Medical Bulletin 25, 148.CrossRefGoogle ScholarPubMed
Compendium Of Licensing Requirements For The Manufacture Of Biological Medicinal Products (1977). Her Majesty's Stationery Office.Google Scholar
Cossart, Y. E. (1977). Evolution of polioviLrus since introduction of attenuated vaccine. British Medical Journal i, 1621.CrossRefGoogle Scholar
Department Of Health And Social Security (1976). Health and Personal Social Services Statistics for England. Her Majesty's Stationery Office.Google Scholar
Furesz, J., Armstrong, R. E., Moreau, P., Yarosh, W. & Nagler, F. P. (1966). Antigenic studies on Sabin Types 1 and 3 poliovaccine virus during 1 to 7 passage in the human intestinal tract. American Journal of Epidemiology 83, 501.CrossRefGoogle ScholarPubMed
Hayflick, L. & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Erperimental Cell Research 25, 585.CrossRefGoogle ScholarPubMed
Hobson, D., Hoskins, J. M., Lane, C. A., Elliott, R. W., Perkins, F. T. & Yetts, B. (1962). Effect of a single dose of oral poliovirus vaccine in persons previously inmiunized with inactivated vaccine. British Medical Journal ii, 145.CrossRefGoogle Scholar
Ikic, D., Manhalter, T., Hrabar, A., Jancikic, B., Juzbasic, M., Lulic, V. & Turner, V.(1970 a). Vaccination against poliomyelitis with live poliovaccine prepared in MKTC and HDC in S.R. Croatia. Proceedings of the Symposium on Human Diploid Cells. Yugoslav Academy of Sciences and Arts, Zagreb, p. 93.Google Scholar
Ikic, D., Hrabar, A., Manhalter, T., Jancikic, B., Jubasic, M., Lulic, V. & Radman, V. (1970 b). Safety of WM-3 poliovirus vaccine. Proceedings of the Symposium on Human Diploid Cells. Yugoslav Academy of Sciences and Arts, Zagreb. p. 105.Google Scholar
Karber, G. (1931). Beitrag zur kooektiven Behandlung pharmakologischer Reinhenversuche. Archiv für experimentelle Pathologie und Pharmakologie 162, 480.CrossRefGoogle Scholar
Macleod, D. R. E. (1966). The neurovirulence of the type 3 Sabin vaccine strain after passage in infants. Canadian Journal of Public Health 57, 37.Google Scholar
Mortimer, P. P. & Cunningham, P. (1975). Sero-immunity to poliovirus in children and young women: England 1972–4. Journal of Hygiene 74, 283.CrossRefGoogle Scholar
Office Of Population Censuses And Surveys (1975). Statistics of Infectious Disease 1975, England and Wales. Series MB2, No. 2. Her Majesty's Stationery Office.Google Scholar
Office Of Population Censuses And Surveys (1978). Monitor for Quarter Ending March. Ref. MB2 78/3. Her Majesty's Stationery Office.Google Scholar
Perkins, F. T. & Evans, D. G. (1959). British standard poliomyelitis antisera types 1, 2 and 3. British Medical Journal i, 1549.CrossRefGoogle Scholar
Sabin, A. B. (1957). Properties and behaviour of orally administered attenuated poliovirus vaccine. Journal of the American Medical Association 164, 1216.CrossRefGoogle ScholarPubMed
Sabin, A. B. (1959). Present position of immunization against poliomyelitis with live virus vaccines. British Medical Journal i, 663.CrossRefGoogle Scholar