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A community outbreak of group A beta haemolytic streptococci with transferable resistance to erythromycin

Published online by Cambridge University Press:  15 May 2009

R. J. D. Scott ,
J. Naidoo ,
N. F. Lightfoot  and
R. C. George
R. J. D. Scott
Affiliation:
Public Health Laboratory, Musgrove Park Hospital, Taunton, Somerset TA1 5DB
J. Naidoo
Affiliation:
Antibiotic Reference Laboratory, Division of Hospital Infection, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
N. F. Lightfoot*
Affiliation:
Public Health Laboratory, Musgrove Park Hospital, Taunton, Somerset TA1 5DB
R. C. George
Affiliation:
Antibiotic Reference Laboratory, Division of Hospital Infection, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
*
†To whom correspondence should be addressed.
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Erythromycin resistance amongst group A streptococci (GAS) in Great Britain is a relatively rare occurrence and outbreaks have been sporadically reported. Over an 8-month period in 1986 ten associated cases occurred in the town of Bridgwater in Somerset. Isolates were group A, type M4 and resistant to erythromycin (MIC 8 mg/l) but sensitive to lincomycin and clindamycin. Erythromycin resistance was transferable from all isolates to a group A recipient strain. No plasmid DNA could be detected in the original isolates or transconjugants.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 1 , February 1989 , pp. 85 - 91
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

Anonymous (1987). Bacterial pharyngitis. Lancet ii, 1241–1242.Google Scholar
Barnham, M. & Cole, G. (1986). Erythromycin resistant beta-haemolytic streptococci in North Yorkshire. Journal of Infection 13, 200–202.Google Scholar
Behnke, D., Golubkov, V., Malke, H., Boltsov, A. & Totolian, A. (1979). Restriction endonuclease analysis of group A streptococcal plasmids determining resistance to macrolides, lincosamides and streptogramin-B antibiotics. FEMS Microbiological Letters 6, 5–9.Google Scholar
Clewell, D. B. (1986). Conjugative transposons and the dissemination of antibiotic resistance in streptococci. Annual Review of Microbiology 40, 635–659.Google Scholar
Clewell, D. B. & Franke, A. E. (1974). Characterisation of a plasmid determining resistance to erythromycin, lincomycin and vernamycin B in a strain of Streptococcus pyogenes. Antimicrobial Agents and Chemotherapy 5, 534–537.Google Scholar
Dixon, J. M. S. & Lipinski, A. E. (1982). Occurrence of antibiotic resistance in haemolytic streptococci. In Microbiology 1982 (ed. Schlesinger, D.), pp. 147–150. Washington, D. C.: American Society for Microbiology.Google Scholar
Hardie, R. (1984). Erythromycin resistant Streptococcus pyogenes in Ayrshire. Communicable Diseases of Scotland 33, xi–xii.Google Scholar
Horodniceanu, T., Bougueleret, L. & Bieth, G. (1981). Conjugative transfer of multiple resistance markers in beta-haemolytic group A, B, F and G streptococci in the absence of extra-chromosomal deoxyribonuclease acid. Plasmid 5, 127–137.Google Scholar
Horodniceanu, T., Bougueleret, L. & Delbos, F. (1979). Phenotypic aspects of resistance to macrolide and related antibiotics in B-haemolytic group A, B, C and G streptococci. In Recent Developments in Laboratory Identification Techniques 1979, (ed. Facklam, R, Laurell, G. and Lind, I.), pp. 122–131. Uppsala: Excerpta Medica.Google Scholar
Horodniceanu, T., Buu-Hoi, A., Le Bouguenec, C. & Bieth, G. (1982). Narrow host range of some streptococcal R plasmids. Plasmid 8, 199–206.Google Scholar
Hyder, S. & Streitfield, M. (1978). Transfer of erythromycin resistance from clinically isolated strains of Streptococcus pyogenes via their endogenous phage. Journal of Infectious Diseases 188, 281–286.Google Scholar
Istre, G. R., Welch, D. F., Marks, M. I. & Moyer, N. (1981). Susceptibility of group A betahaemolytic streptococcus isolates to penicillin and erythromycin. Antimicrobial Agents and Chemotherapy 20, 244–246.Google Scholar
Kohn, J., Hewitt, J. H. & Fraser, C. A. M. (1968). Group A streptococci resistant to lincomycin. British Medical Journal 1, 703.CrossRefGoogle Scholar
Le Bouguenec, C., Horaud, T., Bieth, G., Colimon, R. & Dauguet, C. (1984). Translocation of antibiotic resistance markers from a plasmid-free Streptococcus pyogenes (group A) strain into different streptococcal haemolysin plasmids. Molecular and General Genetics 194, 377–387.Google Scholar
Lowbury, E. J. L. & Hurst, L. (1959). The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin and spiramycin. Journal of Clinical Pathology 12, 163–169.Google Scholar
Maruyama, S., Yoshioka, H., Fujita, K., Takimoto, M. & Satake, Y. (1979). Sensitivity of group A streptococci to antibiotics. American Journal of Diseases in Childhood 133, 1143–1145.Google Scholar
Tadano, J., Kosakai, N., Oguri, T. & Wang, C. M. (1978). A study on beta haemolytic streptococci isolated from the throats of healthy school children in Taiwan: changing patterns of type distribution and drug susceptibility. In Current Chemotherapy 1978 (ed. Siegenthaler, W. and Luthy, R.), pp. 547–550. Washington, D.C.: American Society for Microbiology.Google Scholar
Walker, M., Whetstone, R. J. & Whipp, J. (1984). Erythromycin-resistant Streptococcus pyogenes in Cambridge. Journal of Infection 8, 88–89.Google Scholar
Yagi, Y.. Kessler, R. E., Shaw, J. H., Lopatin, D. E., An, F. & Clewell, D. B. (1983). Plasmid content of Streptococcus faecalis strain 39–5 and identification of a pheromone (CPDI)-induced surface antigen. Journal of General Microbiology 129, 1207–1215.Google Scholar
Youngs, E. R. (1984). Erythromycin-resistant Streptococcus pyogenes in Merseyside. Journal of Infection 8, 86–87.Google Scholar