Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-20T08:30:28.688Z Has data issue: false hasContentIssue false
  • English
  • Français

Combined pertussis-diphtheria prophylactic antigens: An experimental study to determine the specific immunizing value of these antigens used in combination

Published online by Cambridge University Press:  15 May 2009

David Ordman  and
E. Grasset
David Ordman
Affiliation:
From the South African Institute for Medical Research, Johannesburg
E. Grasset
Affiliation:
From the South African Institute for Medical Research, Johannesburg
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Experiments in laboratory animals are described, which were made to determine the specific antibody production following injections of diphtheria and pertussis antigens separately or in combination.

2. Agglutinins to H. pertussis vaccine were not increased or otherwise changed by combining H. pertussis vaccines with either diphtheria anatoxine or A.P.T.

3. A striking enhancement of diphtheria antitoxin production occurred when diphtheria prophylactics were used combined with pertussis vaccine. Such improvement in antitoxin production was most marked in the case of diphtheria anatoxine, but was also shown following the use of A.P.T. in combination with pertussis vaccine.

4. Diphtheria anatoxine combined with H. pertussis vaccine gave no better antitoxin response than did a.p.t. alone.

Type
Research Article
Information
Journal of Hygiene , Volume 46 , Issue 2 , July 1948 , pp. 117 - 122
Copyright
Copyright © Cambridge University Press 1948

References

REFERENCES

Bordet, J. (1936). A propos du vaccin anticoquelucheux. Brux. Méd. 16, 503.Google Scholar
Daughtby-Denmark, L. (1942). Whooping cough vaccine. Amer. J. Dis. Child. 63, 453.Google Scholar
Debré, R. (1932). La vaccination contre la Diphtérie. Paris: Masson et cie.Google Scholar
Foley, A. R. (1946). A three-year experiment with combined diphtheria toxoid-pertussis vaccine. Canad. publ. Hlth. J. 37, 259.Google ScholarPubMed
Glenny, A. T. (1930). Insoluble precipitates in diphtheria and tetanus immunization. Brit. med. J. 2, 244.CrossRefGoogle ScholarPubMed
Kendrick, P. L. (1942). Use of alum-treated pertussis vaccine, and of alum precipitated combined pertussis vaccine and diphtheria toxoid for active immunization. Amer. J. publ. Hlth. 32, 615.CrossRefGoogle ScholarPubMed
Kendrick, P. L. (1943). A field study of alum-precipitated combined pertussis vaccine and diphtheria toxoid for active immunization. Amer. J. Hyg. 38, 193.Google Scholar
Lapin, J. H. (1942). Combined immunization of infants against diphtheria, tetanus and whooping cough. Amer. J. Dis. Child. 63, 225.Google Scholar
Ledingham, J. C. G. (1939). Prophylactic immunization against measles, scarlet fever, diphtheria, whooping cough and influenza. Brit. med. J. 2, 841.CrossRefGoogle Scholar
Mathieson, D. R. (1942). A laboratory evaluation of a combined antigen for diphtheria and whooping cough prophylaxis. J. Bact. 43, 81.Google Scholar
Miller, J. J. Jr & Saito, T. M. (1942). Concurrent immunization against tetanus, diphtheria and pertussis; comparison of fluid and alum precipitated toxoids. J. Pediat. 21, 31.CrossRefGoogle Scholar
Miller, J. J., Humber, J. B. & Dowrie, J. O. (1944). Immunization with combined diphtheria and tetanus toxoids (aluminium hydroxide absorbed) containing Haemophilus pertussis vaccine. J. Pediat. 24, 281.CrossRefGoogle Scholar
Parish, H. J. (1943). Discussion on active immunity. II. Bacterial vaccines and toxoids. Proc. R. Soc. Med. 36, 151.Google Scholar
Ramon, G. (1926). Procédés pour accroître la production des antitoxines. Ann. Inst. Pasteur, 40, 1.Google Scholar
Ramon, G. (1939). Mixed vaccinations. Int. Clin. 1, 241.Google Scholar
Sauer, L. W. & Tucker, W. H. (1942). Simultaneous administration of diphtheria toxoid and pertussis vaccine in young children. Amer. J. publ. Hlth. 32, 385.CrossRefGoogle ScholarPubMed
Sauer, L. W., Tucker, W. H. & Markley, E. (1944). Immunity response to mixtures of diphtheria toxoid and pertussis vaccine. J. Amer. med. Ass. 125, 949.CrossRefGoogle Scholar
Schutze, H. (1940). Simultaneous immunization against whooping cough and diphtheria. Lancet, 2, 192.CrossRefGoogle Scholar
Simon, H. & Craster, C. V. (1941). Simultaneous immunization with a combined diphtheria-whooping cough vaccine: preliminary report of an eighteen-month study. J. med. Soc. N.J., 38, 461.Google Scholar
Steabben, D. B. (1925). Studies on the physiological action of colloids. I. The action of colloidal substances on blood-elements and antibody content. Brit. J. exp. Path. 6, 1.Google Scholar