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A clinical trial of WRL 105 strain live attenuated influenza vaccine comparing four methods of intranasal vaccination

Published online by Cambridge University Press:  15 May 2009

D. S. Freestone ,
C. H. Bowker ,
E. Letley ,
R. D. Ferris ,
W. G. White  and
G. M. Barnes
D. S. Freestone
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
C. H. Bowker
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
E. Letley
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
R. D. Ferris
Affiliation:
The Wellcome Research Laboratories, Beckenham, Kent
W. G. White
Affiliation:
British Leyland UK Limited, Cowley, Oxford
G. M. Barnes
Affiliation:
British Leyland UK Limited, Cowley, Oxford
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Summary

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A single intranasal dose of 107.0 EID50 recombinant WRL 105 strain live attenuated influenza vaccine was administered intranasally to 193 volunteers either as nose drops or by one of three spray devices which produced sprays of differing physical characteristics. In volunteers with homologous haemagglutinating inhibiting antibody titres of ⋜ 20 before vaccination, seroconversion rates varied widely from 80% following the administration of drops to 71%, 57% and 28% with the three spray devices.

In the week following vaccination 16 (22%) of 74 volunteers who were found to show a fourfold or greater antibody response took analgesics to control symptoms in comparison with 4 (7%) of 58 volunteers who exhibited no sero-logical response to vaccination (P < 0.05). However, neither the occurrence of upper respiratory nor systemic symptoms were significantly different in these two groups and the degree of attenuation of the recombinant WRL 105 strain appears to be acceptable for future use.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 3 , June 1976 , pp. 459 - 466
Copyright
Copyright © Cambridge University Press 1976

References

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