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Characterization of the antibody response in Corynebacterium jeikeium septicaemias

Published online by Cambridge University Press:  15 May 2009

I. Clark ,
J. P. Burnie ,
A. P. Coke ,
R. C. Matthews  and
B. A. Oppenheim
I. Clark
Affiliation:
Department of Molecular Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT
J. P. Burnie*
Affiliation:
Department of Molecular Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT
A. P. Coke
Affiliation:
Department of Molecular Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT
R. C. Matthews
Affiliation:
Department of Molecular Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT
B. A. Oppenheim
Affiliation:
Department of Molecular Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT
*
* Author for correspondence.
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Summary

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Corynebacterium jeikeium causes septicaemia in neutropenic patients usually after colonizing intravenous lines. This paper reports the results of immunoblotting sera from 14 patients with a C. jeikeium septicaemia. Recovery from the septicaemia was associated with production of both IgM and IgG against antigenic bands of 50, 52 and 110 kDa. Antibody against the 110 kDa band was present in controls but the antibody against the 50 and 52 kDa was specific to those patients who had on-going or previous C. jeikeium infection. A case of C. jeikeium endocarditis is also presented and here recovery was associated with seroconversion to the 50 and 52 kDa bands.

Type
Research Article
Information
Epidemiology & Infection , Volume 105 , Issue 2 , October 1990 , pp. 229 - 236
Copyright
Copyright © Cambridge University Press 1990

References

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