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The characterization and pathological significance of gastric campylobacter-like organisms in the ferret: a model for chronic gastritis?

Published online by Cambridge University Press:  15 May 2009

D. S. Tompkins ,
J. I. Wyatt ,
B. J. Rathbone  and
A. P. West
D. S. Tompkins
Affiliation:
Department of Microbiology, University of Leeds.
J. I. Wyatt
Affiliation:
Departments of pathology
B. J. Rathbone
Affiliation:
Medicine, St James's University Hospital, Leeds.
A. P. West
Affiliation:
Department of Microbiology, University of Leeds.
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Summary

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Gastric campylobacter-like organisms (CLO) were isolated from gastric tissues removed at sacrifice from 17 mature ferrets; all animals were colonized, but no macroscopic mucosal lesions or histological features of chronic gastritis were seen. The isolates resembled Campylobacter pylori in many cultural and biochemical characteristics, and produced substantial urease activity, but there were sufficient differences from C. pylori to suggest that ferret gastric CLO represents a separate species. Comparison of human C. pylori and ferret gastric CLO may help to clucidate the pathogenicity of the former in patients with gastritis, and the ferret may serve as a useful animal model for the study of C. pylori infection.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 2 , October 1988 , pp. 269 - 278
Copyright
Copyright © Cambridge University Press 1988

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