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The Characteristics of Tubercle Bacilli in Human Bone and Joint Tuberculosis

Published online by Cambridge University Press:  15 May 2009

Arthur Eastwood  and
Fred Griffith
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The material on which this enquiry is based consisted of tuberculous tissue, pus, or fluid obtained from the sources specified in Table II, pp. 260–268.

Type
Research Article
Information
Journal of Hygiene , Volume 15 , Issue 2 , January 1916 , pp. 257 - 309
Copyright
Copyright © Cambridge University Press 1916

References

page 257 note 1 In 23 of these negative cases, egg tubes were inoculated from the spleens, 40 in all, of guinea-pigs killed six weeks after intraperitoneal inoculation with original material. The tubes remained sterile in every instance. This precaution was taken since tubercle bacilli of reduced virulence sometimes fail to produce macroscopic lesions in guinea-pigs, though the bacilli inoculated survive and are recoverable from apparently normal tissues.

page 301 note 1 Subsequently, A. S. Griffith, making an independent investigation of the same virus, has obtained pigmentation on serum.