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A cephalosporin active in vivo against Nocardia: efficacy of cefotaxime in murine model of acute pulmonary nocardiosis

Published online by Cambridge University Press:  19 October 2009

Alan M. Sugar ,
Resham S. Chahal  and
David A. Stevens
Alan M. Sugar
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, Stanford University, Stanford, CA 94305, Institute for Medical Research, San Jose, CA 95128
Resham S. Chahal
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, Stanford University, Stanford, CA 94305, Institute for Medical Research, San Jose, CA 95128
David A. Stevens
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, Stanford University, Stanford, CA 94305, Institute for Medical Research, San Jose, CA 95128
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Summary

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Cefotaxime, a cephalosporin drug, has been shown to be active in vitro against nocardiae, a finding confirmed in this study. Pharmacokinetic studies were performed in mice to define regimens which provided peak serum levels comparable to that achieved in man with currently used doses. These regimens were shown to be effective with only short courses of therapy of rapidly progressive and highly lethal N. asteroides infection, produced by pulmonary challenge of mice. This suggests the possible utility of this drug in human nocardiosis.

Type
Special Feature: Edmond-Isadore-Etienne Nocard
Information
Journal of Hygiene , Volume 91 , Issue 3 , December 1983 , pp. 421 - 427
Copyright
Copyright © Cambridge University Press 1983

References

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