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The British reference preparation for influenza virus haemagglutinin

Published online by Cambridge University Press:  15 May 2009

M. Westwood ,
P. M. Woodward  and
F. T. Perkins
M. Westwood
Affiliation:
National Institute for Medical Research(Hampstead Laboratories) Holly Hill, London, N.W.3
P. M. Woodward
Affiliation:
National Institute for Medical Research(Hampstead Laboratories) Holly Hill, London, N.W.3
F. T. Perkins
Affiliation:
National Institute for Medical Research(Hampstead Laboratories) Holly Hill, London, N.W.3
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Summary

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The two methods for measuring the haemagglutinin content of an influenza virus suspension are the haemagglutinating (HA) and chick cell agglutinating (CCA) techniques and both measure the same biological activity. With the establishment of an international reference preparation for influenza virus haemagglutinin (type A), however, it seems logical to express the haemagglutinin content of influenza vaccines in international units. Accordingly a collaborative study was arranged in order to obtain agreement on the number of units to be assigned to a British reference preparation for influenza haemagglutinin. It was agreed that the preparation contains 190 i.u. per ampoule and 1 i.u. is contained in 0·0622 mg. of the dried material.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 2 , June 1971 , pp. 263 - 271
Copyright
Copyright © Cambridge University Press 1971

References

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