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Binding to and antibacterial effect of ampicillin, neomycin and polymyxin B on human faeces

Published online by Cambridge University Press:  19 October 2009

M. P. Hazenberg ,
A. M. Pennock-Schröder ,
M. Van Den Boom  and
J. P. Van De Merwe
M. P. Hazenberg
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
A. M. Pennock-Schröder
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
M. Van Den Boom
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
J. P. Van De Merwe
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
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Summary

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Neomycin and polymyxin B, used during selective decontamination of the gastrointestinal tract, were studied for their effect on the human faecal flora in vitro. The selective effect was found to be associated with a relative insusceptibility of the obligate anaerobic flora as compared with the facultatively anaerobic Gram-negative rods (Escherichia coli). Both neomycin and polymyxin B were bound by human faeces, in contrast to ampicillin. The results may explain the selective effect of neomycin and polymyxin B on the human flora in vivo.

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 1 , August 1984 , pp. 27 - 34
Copyright
Copyright © Cambridge University Press 1984

References

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