Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-22T15:51:06.654Z Has data issue: false hasContentIssue false
  • English
  • Français

Binding of IgA and/or IgG is a common property among clinical isolates of group A streptococci

Published online by Cambridge University Press:  15 May 2009

G. Lindahl  and
L. Stenberg
G. Lindahl
Affiliation:
Department of Medical Microbiology, University of Lund, Sölvegatan 23, S-223 62 Lund, Sweden
L. Stenberg
Affiliation:
Department of Medical Microbiology, University of Lund, Sölvegatan 23, S-223 62 Lund, Sweden
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Certain strains of group A streptococci are known to bind IgA and/or IgG via a cell surface receptor, which may act as a virulence factor. The distribution of such receptors among routine clinical isolates was studied, using a total of 225 strains and an assay based on the binding of radiolabelled immunoglobulins. Among 194 throat strains isolated during three different time periods in two different geographical areas of Sweden, 82% showed significant binding of IgA and/or IgG. Studies on 31 septicaemia strains, isolated over a period of more than 8 years, showed binding for 84% of the isolates. The binding strains were of several different T-types and could be subdivided into two groups, those binding both IgA and IgG and those binding IgG only. These data show that binding of IgA and/or IgG is a very common property among clinical isolates of group A streptococci.

Type
Special Article
Information
Epidemiology & Infection , Volume 105 , Issue 1 , August 1990 , pp. 87 - 93
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

1.Daly, JD. Resurgence of group A streptococcal disease: Rheumatic fever. Clin Microbiol Newslett 1989; 11: 161–3.CrossRefGoogle Scholar
2.Stevens, DL, Tanner, MH, Winship, J, Swarts, R, Ries, KM, Schlievert, PM, Kaplan, E. Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. N. Engl J Med 1989; 321: 2–7.CrossRefGoogle Scholar
3.Gaworzewska, E, Colman, G. Changes in the patterns of infection caused by Streptococcus pyogenes. Epidemiol Infect 1988; 100: 257–69.CrossRefGoogle ScholarPubMed
4.Fischetti, VA. Streptococcal M protein: Molecular design and biological behavior. Clin Microbiol Rev 1989; 2: 285–314.CrossRefGoogle ScholarPubMed
5.Kronvall, G. A surface component in group A, C, and G streptococci with non-immune reactivity for immunoglobulin G. J. Immunol 1973; 111: 1401–6.Google Scholar
6.Christensen, P, Oxelius, VA. A reaction between some streptococci and IgA myeloma proteins. Acta Path Microbiol Scand Sect C 1975; 83: 184–8.Google Scholar
7.Boyle, MDP, Reis, KJ. Bacterial Fc receptors. Biotechnology 1987; 5: 697–703.Google Scholar
8.Lindahl, G, Akerström, B, Frithz, E, Hedén, LO, Stenberg, L. Protein Arp, the IgA receptor of group A streptococci. In: Boyle, MDP, ed. Bacterial immunoglobulin-biding proteins. Vol I. New York: Academic Press, 1989: 193–200.Google ScholarPubMed
9.Svensson, M, Christensen, P, Schalén, C. Monoclonal opsonic mouse antibodies specific for streptococcal IgG Fc-receptor. J. Med Microbiol 1986; 22: 251–6.CrossRefGoogle ScholarPubMed
10.Frithz, E, Hedèn, LO, Lindahl, G. Extensive sequence homology between IgA receptor and M proteins in Streptococcus pyogenes. Mol Microbiol 1989; 3: 1111–9.CrossRefGoogle Scholar
11.Lebrun, L, Pillot, J, Grangeot-Keros, L, Rannou, M-T. Detection of human Fc (γ) receptors on streptococci by indirect immunofluorescence staining: a survey of streptococci freshly isolated from patients. J Clin Microbiol 1982; 16: 200–1.CrossRefGoogle ScholarPubMed
12.Schmidt, KH, Kühnemund, O, Köhler, W. A screening of streptococci freshly isolated from human and animal sources for binding of human IgG. Zbl Bakt Hyg A 1987; 265: 420–9.Google ScholarPubMed
13.Lindahl, G, Akerström, B. Receptor for IgA in group A streptococci: cloning of the gene and characterization of the protein expressed in Escherichia coli. Mol Microbiol 1989; 3: 239–47.CrossRefGoogle Scholar
14.Martin, PR, Høiby, EA. Streptococcal serogroup A epidemic in Norway 1987–1988. Scand J Inf Dis 1990. In press.CrossRefGoogle ScholarPubMed
15.Lindahl, G. Cell surface proteins of a group A streptococcus type M4: The IgA receptor and a receptor related to M proteins are coded for by closely linked genes. Mol Gen Genet 1989; 216: 372–9.CrossRefGoogle Scholar
16.Health, DG, Cleary, PP. Cloning and expression of the gene for an immunoglobulin G Fc receptor protein from a group A streptococcus. Infect Immun 1987; 55: 1233–8.CrossRefGoogle Scholar
17.Akesson, P, Cooney, J, Kishimoto, F, Björck, L. Protein H-a novel IgG binding bacterial protein. Molec Immunol. (In press).Google Scholar
18.Bisno, AL. The concept of rheumatogenic and nonrheumatogenic group A streptococci, in: Read, SE, Zabriskie, JB, eds. Streptococcal disease and the immune response. New York: Academic Press, 1980; 789–803.Google Scholar