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Attenuation of virulence in Vibrio cholerae

Published online by Cambridge University Press:  15 May 2009

K. Bhaskaran  and
V. B. Sinha
K. Bhaskaran
Affiliation:
Department of Microbiology, Central Drug Research Institute, Lucknow, India
V. B. Sinha
Affiliation:
Department of Microbiology, Central Drug Research Institute, Lucknow, India
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This paper describes the study of a mutant of Vibrio cholerae which is shown to be attenuated by its avirulence to mouse, rabbit and chick embryo. This mutant character is stable, and the avirulence of this strain probably results from its inability to multiply actively in the tissues of the infected animals. The need for the study of such attenuated strains as live vaccines in man is discussed, and certain aspects of immunity to cholera are reviewed.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 2 , June 1967 , pp. 135 - 148
Copyright
Copyright © Cambridge University Press 1967

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