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Attentional function in secondary school students receiving isoniazid prophylaxis for tuberculosis infection

Published online by Cambridge University Press:  01 February 2000

D. ANDERSON ,
V. ANDERSON ,
L. PENTLAND ,
S. SAWYER ,
M. STARR  and
P. D. R. JOHNSON
D. ANDERSON
Affiliation:
Department of Psychology, Royal Children's Hospital, Royal Parade, Parkville, Victoria 3052, Australia
V. ANDERSON
Affiliation:
Department of Psychology, Royal Children's Hospital, Royal Parade, Parkville, Victoria 3052, Australia Department of Psychology, University of Melbourne, Parkville, Victoria 3052, Australia
L. PENTLAND
Affiliation:
Department of Psychology, Royal Children's Hospital, Royal Parade, Parkville, Victoria 3052, Australia
S. SAWYER
Affiliation:
Centre for Adolescent Health, Royal Children's Hospital, Parkville, Australia Department of Respiratory Medicine, Royal Children's Hospital, Parkville, Australia
M. STARR
Affiliation:
Department of Microbiology & Infectious Diseases, Royal Children's Hospital, Parkville, Australia
P. D. R. JOHNSON
Affiliation:
Department of Respiratory Medicine, Royal Children's Hospital, Parkville, Australia Clinical Epidemiology and Biostatistics Unit, Royal Children's Hospital, Parkville, Australia
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Abstract

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Reports have suggested that isoniazid treatment may be associated with poor concentration and subtle reduction in memory. This study examines attentional function and processing speed in a group of 25 adolescents who received isoniazid prophylaxis for at least 6 months. As adolescents often face major educational assessment milestones, such cognitive side effects may have important implications. Participants were assessed before treatment, 1 month into treatment and at least 1 week after treatment cessation. Measures included the Paced Auditory Serial Addition Test and subtests of the appropriate Wechsler scale sensitive to attention and speed of information processing. Isoniazid does not appear to cause significant adverse effects on attentional function in adolescents.

Type
Research Article
Information
Epidemiology & Infection , Volume 124 , Issue 1 , February 2000 , pp. 97 - 101
Copyright
© 2000 Cambridge University Press