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The antigenicity of γ-irradiated vaccinia virus

Published online by Cambridge University Press:  15 May 2009

Colin Kaplan
Colin Kaplan
Affiliation:
Smallpox Vaccine Unit, Lister Institute of Preventive Medicine, Elstree, Hertfordshire, England
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Suspensions and dried preparations of vaccinia virus were exposed to γ-rays in cobalt-60 sources. Suspensions completely inactivated by 6–8 × 105 rad. retained measurable immunogenicity. Dried preparations could not be completely in-activated even by doses of 11 × 106 rad., although the inactivation apparently followed first-order kinetics until about one particle in 107 survived, suggesting that the populations of vaccinia virus in the preparations were heterogeneous.

Type
Research Article
Information
Journal of Hygiene , Volume 58 , Issue 4 , December 1960 , pp. 391 - 398
Copyright
Copyright © Cambridge University Press 1960

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