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The antigenic analysis of haemorrhagic fever with renal syndrome viruses in China by monoclonal antibodies

Published online by Cambridge University Press:  19 October 2009

Z. K. Xu ,
X. L. An  and
M. X. Wang
Z. K. Xu
Affiliation:
Department of Microbiology and Laboratory 403-3, The Fourth Military Medical College, Xian, Shaanxi, China
X. L. An
Affiliation:
Department of Microbiology and Laboratory 403-3, The Fourth Military Medical College, Xian, Shaanxi, China
M. X. Wang
Affiliation:
Department of Microbiology and Laboratory 403-3, The Fourth Military Medical College, Xian, Shaanxi, China
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Thirty-six strains of haemorrhagic fever with renal syndrome (HFRS) virus were isolated from patients and a number of host animals in various areas in China. They were analysed by an immunofluorescence test (IFAT) using 10 monoclonal antibodies (McAbs) specific for the HFRS virus; antigenic differences among the strains have been demonstrated. The HFRS virus strainsrevealed nine different reactions with the McAbs, showing that there are at least nine different antigenic determinants including group-, type- and strain-specific. Analysis of the results shows that antigenic differences among the HFRS virus strains are mainly related to differences in the host animals.

Type
Research Article
Information
Journal of Hygiene , Volume 97 , Issue 2 , October 1986 , pp. 369 - 375
Copyright
Copyright © Cambridge University Press 1986

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