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Antibody titres in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines

Published online by Cambridge University Press:  15 May 2009

Helen Macdonald ,
J. O'H. Tobin ,
J. E. Cradock-Watson ,
Joyce Lomax  and
M. S. Bourne
Helen Macdonald
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
J. O'H. Tobin
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
J. E. Cradock-Watson
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
Joyce Lomax
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
M. S. Bourne
Affiliation:
University of Manchester Student Health Service
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Summary

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Titres of haemagglutination-inhibiting antibody have been measured repeatedly in young women during a period of 6–8 years after the administration of RA27/3 and Cendehill attenuated rubella vaccines. Mean antibody titres were initially 217 after RA27/3 and 159 after Cendehill, but the difference diminished after the first year. Antibody titres were subsequently well maintained in both groups and did not reveal any need for regular revaccination. Mean titres in the Cendehill group were partly maintained by symptomless reinfection which was commoner after Cendehill than after RA27/3. Significant falls in titre were equally common after both vaccines, but low titres of 30 or less were more frequent in subjects who had received Cendehill.

Mean neutralizing antibody titres were initially 15·4 after RA27/3 vaccine and 9 after Cendehill. Titres remained higher after RA27/3 for 3 years, but the difference then diminished and became insignificant during the fifth year.

Revaccination of women with low antibody titres produced significant increases in 69% of subjects when standard RA27/3 vaccine was used; a special preparation of RA27/3 of higher potency produced a similar number of rises (70%) but elicited higher titres and might occasionally be useful for revaccinating women who are likely to come into contact with rubella. Challenge with RA27/3 vaccine produced weaker responses in women who had experienced natural infection than in those whose antibody was vaccine-induced.

Rises in antibody titre after revaccination consisted mainly of IgG, but traces of IgM antibody were detected in one vaccinee who had recently experienced natural reinfection and in 1 woman with naturally acquired antibody who had been challenged with high titre RA27/3 vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 3 , June 1978 , pp. 337 - 347
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Banatvala, J. E. (1977). Rubella vaccines. Recent Advances in Clinical Virology 1, 171.Google Scholar
Best, J. M., Banatvala, J. E. & Bowen, J. M. (1974). New Japanese rubella vaccine: comparative trials. British Medical Journal iii, 221.CrossRefGoogle Scholar
Böttiger, M. & Heller, L. (1976). Experiences from vaccination and revaccination of teenage girls with three different rubella vaccines. Journal of Biological Standardization 4, 107.CrossRefGoogle ScholarPubMed
Boué, A., Nicolas, A. & Montagnon, B. (1971). Reinfection with rubella in pregnant women. Lancet i, 1251.CrossRefGoogle Scholar
Cradock-Watson, J. E., Bourne, M. S. & Vandervelde, E. M. (1972). IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique. Journal of Hygiene 70, 473.CrossRefGoogle ScholarPubMed
Cradock-Watson, J. E., Macdonald, H., Ridehalgh, M. K. S., Bourne, M. S. & Vandervelde, E. M. (1974). Specific immunoglobulin responses in serum and nasal secretions after the administration of attenuated rubella vaccine. Journal of Hygiene 73, 127.CrossRefGoogle ScholarPubMed
Davis, W. J., Larson, H. E., Simsarian, J. P., Parkman, P. D. & Meyer, H. M. Jr (1971). A study of rubella immunity and resistance to infection. Journal of the American Medical Association 215, 600.CrossRefGoogle ScholarPubMed
Department of Health and Social Security (1970). Rubella prophylaxis. Circular 9/70. London: DHSS.Google Scholar
Department of Health and Social Security (1972). Rubella vaccination. Circular 4/72. London: DHSS.Google Scholar
Eilard, T. & Strannegård, Ö. (1974). Rubella reinfection in pregnancy followed by transmission to the fetus. Journal of Infectious Diseases 129, 594.CrossRefGoogle ScholarPubMed
Freestone, D. S., Reynolds, G. M., McKinnon, J. A. & Prydie, J. (1975). Vaccination of schoolgirls against rubella. British Journal of Preventive and Social Medicine 29, 258.Google ScholarPubMed
Grillner, L. (1975). Neutralizing antibodies after rubella vaccination of newly delivered women: a comparison between three vaccines. Scandinavian Journal of Infectious Diseases 7, 169.CrossRefGoogle ScholarPubMed
Horstmann, D. M., Liebhaber, H., Le Bouvier, G. L., Rosenberg, B. A. & Halstead, S. B. (1970). Rubella: reinfection of vaccinated and naturally immune persons exposed in an epidemic. New England Journal of Medicine 283, 771.CrossRefGoogle Scholar
Hutchinson, D. N. & Thompson, K. M. (1965). Continuous rabbit kidney cell cultures in the diagnosis of rubella infections. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 24, 385.Google Scholar
Plotkin, S. A., Farquhar, J. D. & Ogra, P. L. (1973). Immunologic properties of RA27/3 rubella virus vaccine. Journal of the American Medical Association 225, 585.CrossRefGoogle ScholarPubMed
Sharp, D. S. & Macdonald, H. (1973). Use of medroxyprogesterone acetate as a contraceptive in conjunction with early postpartum rubella vaccination. British Medical Journal iv, 443.CrossRefGoogle Scholar
Thompson, K. M. & Tobin, J. O'H. (1970). Isolation of rubella virus from abortion material. British Medical Journal ii, 264.CrossRefGoogle Scholar
Tobin, J. O'H. (1974). The virus laboratory in the diagnosis and prevention of congenital infections. In Intrauterine infections, Ciba Foundation Symposium 10 (new Series), p. 53. Amsterdam: Associated Scientific Publishers.Google Scholar
Zealley, H. (1974). Rubella screening and immunization of schoolgirls: a long-term evaluation. British Journal of Preventive and Social Medicine 28, 54.Google ScholarPubMed