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Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Published online by Cambridge University Press:  15 May 2009

A. E. J. Evans ,
R. L. L. Simmons ,
R. D. Ferris ,
S. K. Hasell ,
E. Letley  and
D. S. Freestone
A. E. J. Evans
Affiliation:
Works Medical Officer, ICI Organics Division, Manchester
R. L. L. Simmons
Affiliation:
Departments of Clinical Immunology and Viral Products Quality Control, The Wellcome Research Laboratories, Beckenham, Kent
R. D. Ferris
Affiliation:
Departments of Clinical Immunology and Viral Products Quality Control, The Wellcome Research Laboratories, Beckenham, Kent
S. K. Hasell
Affiliation:
Departments of Clinical Immunology and Viral Products Quality Control, The Wellcome Research Laboratories, Beckenham, Kent
E. Letley
Affiliation:
Departments of Clinical Immunology and Viral Products Quality Control, The Wellcome Research Laboratories, Beckenham, Kent
D. S. Freestone
Affiliation:
Departments of Clinical Immunology and Viral Products Quality Control, The Wellcome Research Laboratories, Beckenham, Kent
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Summary

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Intranasal vaccination with a single 0·5 ml dose of 107.0 EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAT) antibody in 60 (64·5 %) of 93 volunteers, or in 58 (74·4%) of 78 volunteers with HAI antibody titres before vaccination of ≤ 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6·9 %) of 58 volunteers, or in 3 (14·3%) of 21 volunteers with antibody titres before vaccination of ≤ 1/20.

Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 3 , June 1979 , pp. 489 - 495
Copyright
Copyright © Cambridge University Press 1979

References

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