Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2025-01-05T12:30:57.429Z Has data issue: false hasContentIssue false
  • English
  • Français

Antibody response following smallpox vaccination and revaccination

Published online by Cambridge University Press:  15 May 2009

A. W. Downie ,
L. St Vincent ,
A. R. Rao  and
C. H. Kempe
A. W. Downie
Affiliation:
Department of Pediatrics, University of Colorado Medical Center and the Infectious Disease Hospital, Tondiarpet, Madras
L. St Vincent
Affiliation:
Department of Pediatrics, University of Colorado Medical Center and the Infectious Disease Hospital, Tondiarpet, Madras
A. R. Rao
Affiliation:
Department of Pediatrics, University of Colorado Medical Center and the Infectious Disease Hospital, Tondiarpet, Madras
C. H. Kempe
Affiliation:
Department of Pediatrics, University of Colorado Medical Center and the Infectious Disease Hospital, Tondiarpet, Madras
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Three groups of post-vaccination sera were studied for vaccinial antibody by precipitation, haemagglutinin-inhibition, complement-fixation and neutralization tests. All sera were negative by precipitation and many by haemagglutinin-inhibition and complement-fixation tests, but most showed neutralizing activity at serum dilutions of 1/10 or higher. The differences in antibody titres between the three groups of sera were most probably related to the past history of revaccination.

This investigation was supported in part by Public Health Service Grant AI–1632–16 VR from the National Institute of Allergy and Infectious Diseases, by the World Health Organization and by the Marcus T. Reynolds III Fund.

Type
Research Article
Information
Journal of Hygiene , Volume 67 , Issue 4 , December 1969 , pp. 603 - 608
Copyright
Copyright © Cambridge University Press 1969

References

REFERENCES

Downie, A. W. & Kempe, C. H. (1969). Variola and other pox virus infections. In Diagnostic Procedures for Viral and Rickettsial Diseases (ed. Lennette, & Schmidt, ), 4th ed.New York, American Public Health Association.Google Scholar
Downie, A. W., Fedson, D. S., St Vincent, L., Rao, A. R. & Kempe, C. H. (1969 a). Haemorrhagic smallpox. J. Hyg., Camb. 67, 619–29.Google ScholarPubMed
Downie, A. W., St Vincent, L., Goldstein, L., Rao, A. R. & Kempe, C. H. (1969 b). Antibody response in non-haemorrhagic smallpox patients. J. Hyg., Camb. 67, 609–18.Google ScholarPubMed
Elisberg, B. L., McCown, J. M. & Smadel, J. E. (1956). Vaccination against smallpox. II. Jet injection of chorioallantoic membrane vaccine. J. Immun. 77, 340–51.CrossRefGoogle ScholarPubMed
Espmark, M. A. & Rabo, E. (1965). The formation of neutralizing antibody following smallpox vaccination in young infants with maternal immunity. Acta paediat. scand. 54, 341–7.CrossRefGoogle ScholarPubMed
Herrlich, A., Mayr, A. & Munz, E. (1956). Das Antikörperbild der Variola-Vaccineinfektion. 1. Unterschiedliche Antikörperentwicklung bei der Vaccineinfektion des Kaninchens, Affen und Menschen. Zentbl. Bakt. ParasitKde (I. Abt. Orig.), 166, 72–83.Google Scholar
Kempe, C. H., Dekking, F., St Vincent, L., Rao, A. R. & Downie, A. W. (1969). Conjunctivitis and subclinical infection in smallpox. J. Hyg., Camb. 67, 631–6.Google ScholarPubMed
McCarthy, K., Downie, A. W. & Bradley, W. H. (1958). The antibody response in man following infection with viruses of the pox group. II. Antibody response following vaccination J. Hyg., Camb. 56, 466–78.Google ScholarPubMed
Richardson, G. M. (1941). Preservation of liquid complement serum. Lancet ii, 696–7.Google Scholar