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Antibiotics and the Aberdeen typhoid outbreak in 1964

Published online by Cambridge University Press:  15 May 2009

J. Brodie
J. Brodie
Affiliation:
The Laboratory, City Hospital, Aberdeen
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This paper gives an abbreviated account of part of a research programme which followed the Aberdeen typhoid outbreak of 1964. Chloramphenicol, the main antibiotic used in treatment, was shown to have a minimum inhibitory concentration (MIC) of between 5 and 2.5 μg./ml. for the S. typhi phage type 34 of the outbreak. The MIC for methacycline was between 2.5 and 2 μg./ml. Whereas the deep and shallow broth techniques used gave similar results with these antibiotics, the MIC for ampicillin, and also cephaloridine, was less in the deep than in the shallow broths.

Serum assays in patients given ampicillin or cephaloridine yielded abnormally high concentrations of both antibiotics when S. typhi phage type 34 was the test organism whereas, with other test organisms, the concentrations were within expectation. These abnormally high values fell within expected values when the sera under investigation had first been heated to 56° C. for 30 min. before assay against the S. typhi of the outbreak.

The findings with ampicillin suggested that dosages given were satisfactory. With cephaloridine the concentrations found in patients' sera seemed to show that twice daily doses of 0.5 g. fell short of adequacy.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 2 , April 1976 , pp. 191 - 203
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Brodie, J. (1948). Observations on the differential inhibition of coliform bacilli and rough variants of intestinal pathogens. Journal of General Microbiology 2, 1.CrossRefGoogle Scholar
Brodie, J. & Shepherd, W. (1949). Further observations on the differential inhibition of coliform bacilli and rough variants of intestinal pathogens. Journal of General Microbiology 3, 74.CrossRefGoogle ScholarPubMed
Brodie, J. & Shepherd, W. (1950). The effect of the gas-phase on differential inhibition of intestinal bacilli. Journal of General Microbiology 4, 102.CrossRefGoogle ScholarPubMed
Cruickshank, R. (1962). Mackie and McCartney's Handbook of Bacteriology, 10th ed., revised reprint, p. 407. Edinburgh, London: E. and S. Livingstone.Google Scholar
Garrod, L. P., Lambert, H. P. & O'Grady, F. (1973). Antibiotic and Chemotherapy, 4th ed., p. 278. Edinburgh, London: Churchill Livingstone.Google Scholar
Hermans, P. E., Martin, J. K., Needham, G. M. & Nichols, D. R. (1966). Laboratory and clinical evaluation of cephaloridine, a cephalosporin derivative. Antimicrobial Agents and Chemotherapy, 1965, p. 879. American Society for Microbiology, Michigan, U.S.A.Google Scholar
Muggleton, P. W., O'Callaghan, C. H. & Stevens, W. K. (1964). Laboratory evaluation of a new antibiotic – Cephaloridine (Ceporin). British Medical Journal ii, 1234.CrossRefGoogle Scholar
Russell, E. M. (1965). Typhoid fever in Aberdeen. M.D. Thesis, University of Glasgow.Google Scholar
Walker, W. (1965). The Aberdeen typhoid outbreak of 1964. Scottish Medical Journal 10, 466.CrossRefGoogle ScholarPubMed