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Analysis of influenza A virus reinfection in children in Japan during 1983–91

Published online by Cambridge University Press:  15 May 2009

S. Nakajima ,
F. Nishikawa ,
K. Nakamura  and
K. Nakajima
S. Nakajima
Affiliation:
Department of Microbiology, The Institute of Public Health, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108, Japan
F. Nishikawa
Affiliation:
Saitama Medical School, Saitama 350-4, Japan
K. Nakamura
Affiliation:
Nagano Research Institute for Public Health and Pollution, Nagano 308. Japan
K. Nakajima
Affiliation:
Medical School, Nagoya City University, Aichi 467, Japan
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The epidemiology of influenza A in Japan was studied during 1979–91 and viruses isolated from reinfections during 1983–91 were analysed, Of 2963 influenza viruses isolated during this period, 922 and 1006 were influenza A(H1N1) and A(H3N2) viruses respectively; the others were influenza B viruses. Influenza A(H1N1) and A(H3N2) caused 5 and 6 epidemics respectively, most accompanied by antigenic drift. Seventeen reinfections with H1N1 and 17 with H3N2 were detected during our study. The primary and reinfection strains isolated from 7 H1N1 and 10 H3N2 cases were studied by haemagglutination-inhibition, and amino acid and nucleotide sequences of the HA1 region of the haemagglutinin. Most of the primary and reinfection strains were antigenically and genetically similar to the epidemic viruses circulating at that time. However, in 4 out of 10 cases of reinfection with influenza H3N2 virus, reinfection strains were genetically different from the epidemic viruses.

Type
Research Article
Information
Epidemiology & Infection , Volume 115 , Issue 3 , December 1995 , pp. 591 - 601
Copyright
Copyright © Cambridge University Press 1995

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