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An M-associated protein antigen (MAP) of group A streptococci

Published online by Cambridge University Press:  15 May 2009

Jean P. Widdowson ,
W. R. Maxted  and
Alison M. Pinney
Jean P. Widdowson
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
W. R. Maxted
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
Alison M. Pinney
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
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Summary

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A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 553 - 564
Copyright
Copyright © Cambridge University Press 1971

References

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