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An investigation of the effects of certain substitutes for morphine and heroin upon the passage of food along the alimentary tract of the human subject

Published online by Cambridge University Press:  15 May 2009

G. Norman Myers  and
S. Whately Davidson
G. Norman Myers
Affiliation:
From the Pharmacological Laboratory, University of Cambridge
S. Whately Davidson
Affiliation:
From the Pharmacological Laboratory, University of Cambridge
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1. The effect of heroin, morphine, Dilaudid, Dicodid and Eukodol upon the human alimentary tract are described from observations involving the use of the barium meal and X-ray methods.

2. The effects of Dilaudid closely resemble those of morphine. Dilaudid produces a condition of increased tone in the pyloric and ileo-colic sphincters resulting in delayed emptying of the stomach contents into the duodenum and a delayed passage of the intestinal contents into the caecum.

3. Dicodid has a much weaker action upon the pyloric and ileo-colic sphincters than either morphine, heroin, Dilaudid or Eukodol. It causes only a negligible delay in the passage of food up to the 3 hr. stage, it being normal at the 6 hr. stage owing to a hastening of the motility rate.

4. Eukodol has an action resembling that of morphine and is described.

5. All these drugs possess well-marked analgesic properties.

6. No gross rectal symptoms were observed in any of the subjects under observation.

Type
Research Article
Information
Journal of Hygiene , Volume 38 , Issue 4 , July 1938 , pp. 432 - 445
Copyright
Copyright © Cambridge University Press 1938

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