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An investigation of Neisseria gonorrhoeae by a red cell sensitization technique

Published online by Cambridge University Press:  15 May 2009

I. Chanarin
I. Chanarin
Affiliation:
Central Pathological Laboratory, Durban
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Two antigens, probably polysaccharide in nature, were extracted from smoothgonococci.

One of these could be adsorbed on to red cells and sensitized these cells to the action of a gonococcal antiserum. The factors concerned in this adsorption were investigated. The antigen, which was shown by a mirror absorption technique to be of two distinct types, was lost with the S-R change.

The second antigen was detected by its ability to fix complement in the presence of an immune serum.

It is suggested that these two antigens form a complex which determines the nature of the surface of the smooth gonococcus.

I wish to thank Dr J. C. Thomas, Provincial Pathologist, for the facilities for carrying out these investigations; Prof. M. van den Ende and Dr A. Kipps for helpful and constructive criticism; and Miss E. Bennett, Miss B. Jefferies, Mr L. Heitman, Mrs S. Maddison, and Mr G. C. Buckle for technical assistance.

Type
Research Article
Information
Journal of Hygiene , Volume 52 , Issue 4 , December 1954 , pp. 425 - 443
Copyright
Copyright © Cambridge University Press 1954

References

Atkin, E. E. (1925). Brit. J. exp. Path. 6, 235.Google Scholar
Cook, M. W. & Stafford, D. D. (1921). J. infect. Dis. 29, 561.CrossRefGoogle Scholar
Goodner, K. & Horsfall, F. L. (1936). J. exp. Med. 64, 201.CrossRefGoogle Scholar
Hermanies, J. (1921). J. infect. Dis. 28, 132.CrossRefGoogle Scholar
Miravent, J-M., Quiroga, R. & Negroni, P. (1926). C.R. Soc. Biol., Paris, 95, 1166.Google Scholar
Neter, E. & Zalewski, N. J. (1953). J. Bact. 66, 424.CrossRefGoogle Scholar
Oliver, J. O. Personal communication to Thomas, R. B. & Bayne-Jones, S. (1936). Amer. J. Syph. Gonor. Ven. Dis. (Suppl.), 20, 1.Google Scholar
Price, I. N. O. (1933). The complement-fixation test for Gonorrhoea. London County Council.Google Scholar
Reyn, A. (1949). Acta. path. microbiol. scand. 26, 234, 252.CrossRefGoogle Scholar
Segawa, N. (1932). Zbl. Bakt. (Abt. I. Orig.), 124, 261, 264, 266.Google Scholar
Stokinger, H. E., Carpenter, C. M. & Plack, J. (1944). J. Bact. 47, 149.CrossRefGoogle Scholar
Thomas, J. C. & Mennie, A. T. (1950). Lancet, 2, 745.CrossRefGoogle Scholar
Thomsen, O. & Vollmond, E. (1921). C.R. Soc. Biol., Paris, 84, 326.Google Scholar
Torrey, J. C. & Buckell, G. T. (1922). J. Immunol. 7, 305.CrossRefGoogle Scholar
Tulloch, W. J. (1923). J. R. Army Med. Cps, 40, 12, 98.Google Scholar
Warren, S. H. (1921). J. Path. Bact. 24, 424.CrossRefGoogle Scholar